Endocrine function after immunosuppression of pancreatic allograft by ionizing irradiation in the primate

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dc.contributor.authorDu Toit D.F.
dc.contributor.authorHeydenrych J.J.
dc.contributor.authorSmit B.
dc.date.accessioned2011-05-15T16:05:06Z
dc.date.available2011-05-15T16:05:06Z
dc.date.issued1986
dc.description.abstractThe object of this prliminary study was to evaluate the endocrine function after heterotopic intraperitoneal segmental pancreatic allotransplantation with unligated duct in irradiated, totally pancreatectomized primates. All allograft recipients received, pre- and peroperative donor-specific blood transfusions and peroperative external irradiation from a linear accelerator; 200 rads was administered weekly and increased to a total dose of 1,5000 rads. Pancreatic transplantation was performed between 2 and 6 weeks after completion of irradiation and preoperative blood transfusions. As previously reported, only minimal pancreatic allograft survival was achieved following preoperative irradiation. One recipient remained normoglycaemic for > 100 days after transplantation, the longest surviving pancreatic allograft recipient reported from this laboratory. Intravenous glucose tolerance test results in this recipient revealed normoglycaemia, reduced K-value, hypoinsulinaemia, normal glucagon response, reduced C-peptide values, and moderate glucose intolerance. Aortography and electron-microscopic examination of allograft biopsy tissue confirmed the presence of a functioning allograft.
dc.description.versionArticle
dc.identifier.citationJournal of Surgical Oncology
dc.identifier.citation32
dc.identifier.citation1
dc.identifier.issn224790
dc.identifier.urihttp://hdl.handle.net/10019.1/12971
dc.subjectanimal experiment
dc.subjectape
dc.subjectendocrine system
dc.subjectendocrinology
dc.subjectglucose tolerance
dc.subjectimmunosuppressive treatment
dc.subjectinsulin release
dc.subjectirradiation
dc.subjectnonhuman
dc.subjectpancreas transplantation
dc.subjectpriority journal
dc.subjecttherapy
dc.subjectAnimal
dc.subjectFemale
dc.subjectImmunity
dc.subjectImmunosuppression
dc.subjectLymphoid Tissue
dc.subjectMale
dc.subjectPancreas
dc.subjectPancreas Transplantation
dc.subjectPancreatic Function Tests
dc.subjectPapio
dc.subjectParticle Accelerators
dc.subjectSupport, Non-U.S. Gov't
dc.subjectTransplantation Immunology
dc.subjectWhole-Body Irradiation
dc.titleEndocrine function after immunosuppression of pancreatic allograft by ionizing irradiation in the primate
dc.typeArticle
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