Free radical damage to chromatin

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dc.contributor.advisorBohm, Lotharen_ZA
dc.contributor.advisorDizdaroglu, M.en_ZA
dc.contributor.authorNackerdien, Zeena Elnisaen_ZA
dc.contributor.otherStellenbosch University. Faculty of Medicine and Health Sciences. Department of Biomedical Sciences: Molecular Biology and Human Genetics
dc.date.accessioned2012-08-27T11:38:45Z
dc.date.available2012-08-27T11:38:45Z
dc.date.issued1993-03
dc.descriptionThesis (PhD)--University of Stellenbosch, 1993.
dc.description.abstractENGLISH ABSTRACT: Oxygen-derived free radicals are implicated in many human diseases including cancer. The mutagenic and carcinogenic properties of these species manifest themselves in lingering damage to several biomolecules including DNA. Here, efforts have been made to chemically characterize DNA base damage and DNA-protein cross-links produced in isolated chromatin and in cultured mammalian cells exposed to ionizing radiation or to H2O2/metal ions. Gas chromatography/mass spectrometry with selected ion-monitoring was used for this purpose.en_ZA
dc.description.abstractAFRIKAANSE OPSOMMING: Vry radikaal derivate van suurstof word geimpliseer in verskeie siektes insluitende kanker. Mutasies en kankerwekkende eienskappe van hierdie spesies word geopenbaar deur langdurige skade aan verskeie biomolekules insluitende DNS. Geisoleerde kromatien sowel as kromatien afkomstig van gekultureerde soogdier selle is hier ionies bestraal of behandel met H2O2/metaal ione. Chemiese skade berokken aan DNS basisse en DNS-protein kruisverbindings is met behulp van gas chromotografie/massa spektrometrie (insluitende geselekteerde ion-waarneming) gemonitor.af_ZA
dc.description.versionDoctoralen_ZA
dc.format.extent124 pages
dc.identifier.urihttp://hdl.handle.net/10019.1/57987
dc.language.isoen_ZA
dc.publisherStellenbosch : Stellenbosch University
dc.rights.holderStellenbosch University
dc.subjectChromatinen_ZA
dc.subjectDissertations -- Medicineen_ZA
dc.subjectUCTDen_ZA
dc.titleFree radical damage to chromatinen_ZA
dc.typeThesisen_ZA
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