A pilot study of deep sclerectomy with implantation of chromic suture material as a collagen implant: Medium-term results

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dc.contributor.authorWevill M.T.
dc.contributor.authorMeyer D.
dc.contributor.authorVan Aswegen E.
dc.date.accessioned2011-05-15T16:16:24Z
dc.date.available2011-05-15T16:16:24Z
dc.date.issued2005
dc.description.abstractAims: A pilot study of the safety and efficacy of deep sclerectomy with a chromic suture implant (DSCI) for open angle glaucoma. Methods: This prospective trial involved 23 eyes of 16 consecutive patients with uncontrolled open angle glaucoma. The DSCI procedure involved radial suturing of a 2mm piece of 1/0 chromic suture as an implant. Intraocular pressure (IOP) measurements and eye examinations were performed preoperatively and regularly postoperatively for up to 66 months. Results: The mean follow-up period was 36.3 (SD 19.9) months. The mean preoperative IOP was 26.3 (SD 8.5)mmHg. The mean postoperative IOP was 14.1 (SD 2.8)mmHg at month 12, and 16.5 (SD 2.3)mmHg at 36 months. Complete success rate, defined as an IOP lower than 21mmHg without medication was 77% of eyes at 36 months. Qualified success rate, defined as an IOP lower than 21mmHg with medication, was 100% at 36 months. Paired t-test and Wilcoxon test analysis of preoperative vs postoperative IOP at 36 months indicated a significant reduction in IOP, Intraoperative complications included rupture of the trabecular meshwork in seven eyes. Exclusion of these patients from the results analysis revealed a mean follow-up of 37.1 months (SD 9), preoperative mean IOP was 25.9mmHg (SD 4.1), 12-month mean IOP was 13.4mmHg (SD 2.8), and 36-month mean IOP 16.6mmHg (SD 2.1). Early postoperative complications included hyphaema in two eyes and dislocation of implant in one eye. One eye developed a central retinal vein occlusion and cataract progression occurred in one eye. The mean postoperative duration of use of topical dexamethasone was 5.4 months (SD 2). Conclusions: DSCI using a chromic suture implant provides good control of IOP at medium-term follow-up with few postoperative complications. Prolonged use of postoperative anti-inflammatory medication was necessary. © 2005 Nature Group All rights reserved.
dc.description.versionArticle
dc.identifier.citationEye
dc.identifier.citation19
dc.identifier.citation5
dc.identifier.issn0950222X
dc.identifier.other10.1038/sj.eye.6701541
dc.identifier.urihttp://hdl.handle.net/10019.1/13769
dc.subjectbetamethasone acetate plus betamethasone sodium phosphate
dc.subjectcollagen implant
dc.subjectdexamethasone
dc.subjectdexamethasone sodium phosphate
dc.subjectmitomycin C
dc.subjectaged
dc.subjectarticle
dc.subjectcataract
dc.subjectclinical article
dc.subjectclinical trial
dc.subjectcontrolled clinical trial
dc.subjectcontrolled study
dc.subjectdisease control
dc.subjectfemale
dc.subjectfollow up
dc.subjecthuman
dc.subjectimplantation
dc.subjectintraocular pressure
dc.subjectmale
dc.subjectopen angle glaucoma
dc.subjectpilot study
dc.subjectpostoperative care
dc.subjectpostoperative complication
dc.subjectpostoperative inflammation
dc.subjectpreoperative evaluation
dc.subjectprospective study
dc.subjectrank sum test
dc.subjectretina vein occlusion
dc.subjectsafety
dc.subjectsclerectomy
dc.subjectsurgical technique
dc.subjectsuture
dc.subjecttrabecular meshwork
dc.subjecttreatment outcome
dc.subjectvisual system examination
dc.subjectAged
dc.subjectDexamethasone
dc.subjectDrug Administration Schedule
dc.subjectEpidemiologic Methods
dc.subjectFemale
dc.subjectGlaucoma, Open-Angle
dc.subjectGlucocorticoids
dc.subjectHumans
dc.subjectIntraocular Pressure
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPostoperative Care
dc.subjectPostoperative Complications
dc.subjectSclerostomy
dc.subjectSuture Techniques
dc.subjectSutures
dc.titleA pilot study of deep sclerectomy with implantation of chromic suture material as a collagen implant: Medium-term results
dc.typeArticle
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