Adult T-cell leukaemia / lymphoma in an adolescent patient : expect the unexpected

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dc.contributor.authorAbdullah, Ibtisamen_ZA
dc.contributor.authorNell, Erica-Marien_ZA
dc.contributor.authorChapanduka, Zivanai C.en_ZA
dc.date.accessioned2020-09-22T06:51:56Z
dc.date.available2020-09-22T06:51:56Z
dc.date.issued2020-05-25
dc.descriptionCITATION: Abdullah, I., Nell, E. M. & Chapanduka, Z. C. 2020. Adult T-cell leukaemia / lymphoma in an adolescent patient : expect the unexpected. South African Journal of Oncology, 4:a121, doi:10.4102/sajo.v4i0.121.
dc.descriptionThe original publication is available at https://sajo.org.za
dc.description.abstractENGLISH ABSTRACT: This case study explores a clinicopathological presentation of Adult T-cell leukaemia/lymphoma (ATLL) at Tygerberg Hospital; a disease associated with adulthood noted in an adolescent patient. Adult T-cell leukaemia–lymphoma oncogenesis develops through a multistep process with an accumulation of mutations. Infection through human T-lymphotropic virus type 1 (HTLV-1) is the first step of a multistep process resulting in eventual clonal proliferation of mature T-cells. There is a long latency period of 20–50 years from the time of infection with HTLV-1 to the development of symptoms of ATLL; thus, ATLL is a malignancy associated with adulthood. The median age of diagnosis is 58, ranging from the third to ninth decade of life. This is an ideal learning case as it highlights the importance of recognising ATLL in children and young adults in our population.en_ZA
dc.description.urihttps://sajo.org.za/index.php/sajo/article/view/121
dc.description.versionPublisher's version
dc.format.extent4 pagesen_ZA
dc.identifier.citationAbdullah, I., Nell, E. M. & Chapanduka, Z. C. 2020. Adult T-cell leukaemia / lymphoma in an adolescent patient : expect the unexpected. South African Journal of Oncology, 4:a121, doi:10.4102/sajo.v4i0.121
dc.identifier.issn2523-0646 (online)
dc.identifier.issn2518-8704 (print)
dc.identifier.otherdoi:10.4102/sajo.v4i0.121
dc.identifier.urihttp://hdl.handle.net/10019.1/108834
dc.language.isoen_ZAen_ZA
dc.publisherAOSISen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectFlower cellsen_ZA
dc.subjectHuman T-cell leukemia-lymphoma virusesen_ZA
dc.subjectLymphoproliferative disordersen_ZA
dc.subjectAdolescentsen_ZA
dc.titleAdult T-cell leukaemia / lymphoma in an adolescent patient : expect the unexpecteden_ZA
dc.typeArticleen_ZA
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