Cyclic AMP mediated arrhythmias induced in the ischaemic pig heart

Simple item page
dc.contributor.authorPodzuweit T.
dc.contributor.authorEls D.J.
dc.contributor.authorMcCarthy J.
dc.date.accessioned2011-05-15T16:15:40Z
dc.date.available2011-05-15T16:15:40Z
dc.date.issued1981
dc.description.abstractLigation of the anterior descending coronary artery two-thirds from its origin in the pig was found to precipitate ventricular arrhythmias and fibrillation, starting approximately 20 min post-ligation, which were associated with regional accumulation of myocardial cAMP in the ischaemic area. When the arrhythmias stopped, cyclic AMP levels in the ischaemic zone were decreased. Arrhythmias could then be induced by subepicardial infusion (10 μl/min) close to the visible edge of ischaemia of cAMP analogues [N6-monobutyryl cAMP, N6,O2'-dibutyryl cAMP to (5.10-2 M each)] or agents which increase the myocardial contents of cAMP. These agents were: isoproterenol (10-6 M), noradrenalin, adrenalin (10-5 M each), glucagon, histamine (10-3 M each), theophylline and caffeine (5.10-2 M). Also active were dopamine (10-3 M), oubain (10-5 M) and aconitine (10-6 M). The arrhythmias induced by infusion of catecholamines were dependent on Ca2+ and were abolished by beta-adrenoceptor blocking agents (pindolol, 10-6 M) and calcium antagonists (isoptin, D 600, 10-4 M each). Infusion of 150 mM sodium chloride or 100 mM sodium butyrate did not precipitate arrhythmias. It is concluded that myocardial cAMP may play an important role in the genesis of ventricular arrhythmias in the ischaemic heart, probably by augmenting the slow calcium inward current.
dc.description.versionArticle
dc.identifier.citationBasic Research in Cardiology
dc.identifier.citation76
dc.identifier.citation4
dc.identifier.issn03008428
dc.identifier.urihttp://hdl.handle.net/10019.1/13440
dc.subjectcyclic amp
dc.subjectanimal experiment
dc.subjectheart
dc.subjectheart muscle ischemia
dc.subjectheart ventricle arrhythmia
dc.subjectswine
dc.subjectAdrenergic beta-Antagonists
dc.subjectAnimal
dc.subjectArrhythmia
dc.subjectCalcium Channel Blockers
dc.subjectCatecholamines
dc.subjectCoronary Circulation
dc.subjectCyclic AMP
dc.subjectFemale
dc.subjectLactates
dc.subjectLigation
dc.subjectMale
dc.subjectMyocardium
dc.subjectSupport, Non-U.S. Gov't
dc.subjectSwine
dc.titleCyclic AMP mediated arrhythmias induced in the ischaemic pig heart
dc.typeArticle
Files
Collections
Stellenbosch University - Scopus Tygerberg Hospital Publications