Effects of nifedipine on the peri-operative ECG, as determined by continuous Holter monitoring : a double-blind study

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dc.contributor.authorDu Toit, H. J.en_ZA
dc.contributor.authorWeich, H. F. H.en_ZA
dc.contributor.authorWeymar, H. W.en_ZA
dc.contributor.authorPrzybojewski, J. Z.en_ZA
dc.date.accessioned2011-03-18T14:59:40Z
dc.date.available2011-03-18T14:59:40Z
dc.date.issued1986-03en_ZA
dc.descriptionPlease cite as follows: Du Toit, H. J., Weich, H. F. H., Weymar, H. W. & Przybojewski, J. Z. 1986. Effects of nifedipine on the peri-operative ECG, as determined by continuous Holter monitoring: A double-blind study. S Afr Med J, 69:427-431.en_ZA
dc.descriptionThe original publication is available at http://www.samj.org.zaen_ZA
dc.description.abstractA double-blind study was performed on 50 elderly patients undergoing hip-replacement surgery under general anaesthesia; 26 were given nifedipine and the remaining 24 placebo to determine effects on the continuously monitored (Holter) ECG during the 4 peri-operative days. Drugs were only administered during the latter 3 days of the observation period. Surgery was performed on the morning of the 3rd day. A striking feature was a high incidence of arrhythmias in both groups of patients, a finding previously documented in both 'normal' and elderly people. A decrease in ST-segment changes was expected in the nifedipine-treated patients. An unexpected finding, therefore, was the lack of protection against cardiac ischaemic changes in the nifedipine-treated patients compared with the placebo patients. Interpretation of the ST segment as seen in the Holter-monitored ECG remains controversial. We have no clear explanation for the lack of protection against ischaemic changes. The effects of profound vasodilatation produced by nifedipine in elderly patients subjected to major surgery, general anaesthesia including administration of enflurane, and a variable amount of blood loss in the postoperative period may be important factors. In conclusion, one should perhaps be cautious of nifedipine administration under these circumstances.en_ZA
dc.description.versionPublishers versionen_ZA
dc.identifier.citationDu Toit, H. J., Weich, H. F. H., Weymar, H. W. & Przybojewski, J. Z. 1986. Effects of nifedipine on the peri-operative ECG, as determined by continuous Holter monitoring: A double-blind study. S Afr Med J, 69:427-431.en_ZA
dc.identifier.issn2078-5135 (online)en_ZA
dc.identifier.issn0256-9574 (print)en_ZA
dc.identifier.urihttp://hdl.handle.net/10019.1/7970
dc.language.isoen_ZAen_ZA
dc.publisherHealth & Medical Publishing Groupen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectHypotensive agentsen_ZA
dc.subjectNifedipineen_ZA
dc.subjectPlacebos (Medicine)en_ZA
dc.subjectVasodilatorsen_ZA
dc.subjectChemotherapyen_ZA
dc.subjectElectrocardiographyen_ZA
dc.subjectCoronary heart diseaseen_ZA
dc.subjectOral drug administrationen_ZA
dc.subjectAnesthesia, Inhalationen_ZA
dc.subjectArrhythmiaen_ZA
dc.titleEffects of nifedipine on the peri-operative ECG, as determined by continuous Holter monitoring : a double-blind studyen_ZA
dc.typeArticleen_ZA
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