The effect of methylprednisolone, given prior to cardiopulmonary bypass, on indices of gas exchange

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dc.contributor.authorCoetzer M.
dc.date.accessioned2011-05-15T15:56:45Z
dc.date.available2011-05-15T15:56:45Z
dc.date.issued1996
dc.description.abstractThis study examined the effect of a single dose of methyl-prednisolone ((MP) 30 mg/kg) given before cardiopulnionary bypass (CPB) on the alveolar/arterial oxygen gradient (AaDO2) and arterial oxygen tension/inspired oxygen fraction quotient (PaO2/FiO2) at 1, 24 and 48 hours after CPB. The study was prospective and patients were randomly allocated to one of two groups. Of the 295 patients entered into the study, 165 received MP and 130 did not. The mortality rate in the MP group was 4.24% and in the control group the mortality rate was 3.85% (P = 0.894). No difference in the postoperative PaO2/FiO2 and AaDO2 could be demonstrated when patients who had received MP were compared with those who had not received MP pre-operatively.
dc.description.versionArticle
dc.identifier.citationCardiovascular Journal of South Africa
dc.identifier.citationSUPPL. 4
dc.identifier.issn10159657
dc.identifier.urihttp://hdl.handle.net/10019.1/10025
dc.subjectmethylprednisolone
dc.subjectadult
dc.subjectaged
dc.subjectarterial oxygen tension
dc.subjectarticle
dc.subjectblood gas analysis
dc.subjectcardiopulmonary bypass
dc.subjectcardiovascular function
dc.subjectclinical trial
dc.subjectcomplement activation
dc.subjectcontrolled clinical trial
dc.subjectcontrolled study
dc.subjectdrug effect
dc.subjectfemale
dc.subjectgas exchange
dc.subjectheart output
dc.subjecthuman
dc.subjectintravenous drug administration
dc.subjectlung alveolus oxygen tension
dc.subjectlung function
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectrandomized controlled trial
dc.titleThe effect of methylprednisolone, given prior to cardiopulmonary bypass, on indices of gas exchange
dc.typeArticle
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