Efficiency of co-expression of transcription factors Pdx1, Ngn3, NeuroD and Pax6 with insulin : a statistical approach

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dc.contributor.authorDu Toit, Don F., 1946-en_ZA
dc.contributor.authorLongo-Mbenza, Benjaminen_ZA
dc.contributor.authorPage, Benedict J.en_ZA
dc.contributor.authorTchokonte-Nana, Venanten_ZA
dc.contributor.otherStellenbosch University. Dept. of Biomedical Sciences, Division of Anatomy and Histologyen_ZA
dc.date.accessioned2014-07-06T17:15:55Z
dc.date.available2014-07-06T17:15:55Z
dc.date.issued2015-05
dc.descriptionCITATION: Du Toit, DF, Longo-Mbenza, B, Page, BJ, & Tchokonte-Nana, V. 2015. Efficiency of co-expression of transcription factors Pdx1, Ngn3, NeuroD and Pax6 with insulin: A statistical approach, 3(1):57-64. https://doi.org/10.1016/j.ijdm.2011.01.007.en_ZA
dc.descriptionThe original publication is available https://www.sciencedirect.com/journal/international-journal-of-diabetes-mellitusen_ZA
dc.description.abstractAim: The objective of this study was to investigate the time related profile and efficiency of co-expression of the homeodomain proteins Pdx1, NeuroD, Ngn3, Pax6 and caspase3 with insulin, and to establish the time periods post PDL optimum for islets transplantation. Study design/methods: In this experimental study, immunofluorescent staining procedure was performed on deparaffinized pancreatic duct ligated (PDL) tissues of 78 Sprague–Dawley rats. Quantification of protein coexpression was made using a computerized morphometry. The efficiency of co-expression was arbitrary defined by the value of mean ratio (score without unit) of insulin expression divided by each expression index of the other proteins, occurring within the time interval of 12–24 h post PDL. Statistical tool was used to analyze the efficiency of co-expression of proteins; analysis of variances (one way ANOVA) was used to compare the means of co-expression indexes across the time periods pre- and post PDL. P-values less than 0.05 were considered statistically significant; no post hoc test was done.en_ZA
dc.description.urihttps://www.sciencedirect.com/science/article/pii/S1877593411000087en_ZA
dc.description.versionPublishers versionen_ZA
dc.identifier.citationDu Toit, DF, Longo-Mbenza, B, Page, BJ, & Tchokonte-Nana, V. 2015. Efficiency of co-expression of transcription factors Pdx1, Ngn3, NeuroD and Pax6 with insulin: A statistical approach. International journal of diabetes mellitus, 3(1):57-64. https://doi.org/10.1016/j.ijdm.2011.01.007.en_ZA
dc.identifier.issn1877-5942 (online)en_ZA
dc.identifier.issn1877-5934 (print)en_ZA
dc.identifier.otherdoi:10.1016/j.ijdm.2011.01.007en_ZA
dc.identifier.urihttp://hdl.handle.net/10019.1/87855
dc.language.isoen_ZA
dc.publisherElsevier
dc.rights.holderInternational Journal of Diabetes Mellitusen_ZA
dc.subjectInsulin -- Effectivenessen_ZA
dc.subjectIslands of Langerhans -- Transplantation -- Effectivenessen_ZA
dc.titleEfficiency of co-expression of transcription factors Pdx1, Ngn3, NeuroD and Pax6 with insulin : a statistical approachen_ZA
dc.typeArticleen_ZA
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