In vitro activity of tigecycline and comparators against Gram-positive and Gram-negative isolates collected from the Middle East and Africa between 2004 and 2011

dc.contributor.authorKanj, Souhaen_ZA
dc.contributor.authorWhitelaw, Andrewen_ZA
dc.contributor.authorDowzicky, Michael J.en_ZA
dc.date.accessioned2016-06-21T06:30:08Z
dc.date.available2016-06-21T06:30:08Z
dc.date.issued2014
dc.descriptionCITATION: Kanj, S., Whitelaw, A. & Dowzicky, M.J. 2014. In vitro activity of tigecycline and comparators against Gram-positive and Gram-negative isolates collected from the Middle East and Africa between 2004 and 2011. International Journal of Antimicrobial Agents, 43(2): 170–178, doi: 10.1016/j.ijantimicag.2013.10.011.en_ZA
dc.descriptionThe original publication is available at http://www.ijaaonline.comen_ZA
dc.description.abstractThe Tigecycline Evaluation and Surveillance Trial (T.E.S.T.) was established in 2004 to monitor longitudinal changes in bacterial susceptibility to numerous antimicrobial agents, specifically tigecycline. In this study, susceptibility among Gram-positive and Gram-negative isolates between 2004 and 2011 from the Middle East and Africa was examined. Antimicrobial susceptibilities were determined using Clinical and Laboratory Standards Institute (CLSI) interpretive criteria, and minimum inhibitory concentrations (MICs) were determined by broth microdilution methods. US Food and Drug Administration (FDA)-approved breakpoints were used for tigecycline. In total, 2967 Gram-positive and 6322 Gram-negative isolates were examined from 33 participating centres. All Staphylococcus aureus isolates, including meticillin-resistant S. aureus, were susceptible to tigecycline, linezolid and vancomycin. Vancomycin, linezolid, tigecycline and levofloxacin were highly active (>97.6% susceptibility) against Streptococcus pneumoniae, including penicillin-non-susceptible strains. All Enterococcus faecium isolates were susceptible to tigecycline and linezolid, including 32 vancomycin-resistant isolates. Extended-spectrum β-lactamases were produced by 16.6% of Escherichia coli and 32.9% of Klebsiella pneumoniae. More than 95% of E. coli and Enterobacter spp. were susceptible to amikacin, tigecycline, imipenem and meropenem. The most active agents against Pseudomonas aeruginosa and Acinetobacter baumannii were amikacin (88.0% susceptible) and minocycline (64.2% susceptible), respectively; the MIC90 (MIC required to inhibit 90% of the isolates) of tigecycline against A. baumannii was low at 2 mg/L. Tigecycline and carbapenem agents were highly active against most Gram-negative pathogens. Tigecycline, linezolid and vancomycin showed good activity against most Gram-positive pathogens from the Middle East and Africa.en_ZA
dc.description.urihttp://www.ijaaonline.com/article/S0924-8579(13)00375-0/abstract
dc.description.versionPost print version
dc.format.extent45 pages
dc.identifier.citationKanj, S., Whitelaw, A. & Dowzicky, M.J. 2014. In vitro activity of tigecycline and comparators against Gram-positive and Gram-negative isolates collected from the Middle East and Africa between 2004 and 2011. International Journal of Antimicrobial Agents, 43(2): 170–178, doi: 10.1016/j.ijantimicag.2013.10.011en_ZA
dc.identifier.issn1872-7913 (online)
dc.identifier.issn0924-8579 (Print)
dc.identifier.otherdoi: 10.1016/j.ijantimicag.2013.10.011
dc.identifier.urihttp://hdl.handle.net/10019.1/99044
dc.language.isoen_ZAen_ZA
dc.publisherElsevieren_ZA
dc.rights.holderElsevieren_ZA
dc.subjectAnti-infective agentsen_ZA
dc.subjectBacterial diseases -- Chemotherapyen_ZA
dc.subjectGram-positive bacterial infections -- Chemotherapyen_ZA
dc.subjectGram-negative bacteria -- Chemotherapyen_ZA
dc.subjectDrug resistance in microorganismsen_ZA
dc.titleIn vitro activity of tigecycline and comparators against Gram-positive and Gram-negative isolates collected from the Middle East and Africa between 2004 and 2011en_ZA
dc.typeArticleen_ZA
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