Short communication: Simplified estimation of the long-term specificity of the BED assay to improve estimates of HIV incidence

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dc.contributor.authorHargrove J.
dc.contributor.authorHumphrey J.
dc.date.accessioned2011-05-15T16:03:20Z
dc.date.available2011-05-15T16:03:20Z
dc.date.issued2010
dc.description.abstractThe BED assay overestimates HIV incidence because a proportion, epsilon (ω), of chronically infected people test "false-recent." In the ZVITAMBO trial, 2796 postpartum women tested HIV positive at baseline and 5.1% tested "false-recent" by BED 12 months later, providing a population-based estimate of ω. At baseline, 7.2% (95% CI: 5.3-9.4) of positive women >30 years and 5.1% (95% CI: 3.5-7.2) of positive women with CD4 <200 cells/μl tested "recent" by BED. Thus, the proportions of BED-positive women in either of these subgroups (data that would be available in surveys measuring HIV and BED status) provided a reasonably tight upper bound for ω, which can be used to provide a lower bound for HIV incidence. © 2010, Mary Ann Liebert, Inc.
dc.description.versionArticle
dc.identifier.citationAIDS Research and Human Retroviruses
dc.identifier.citation26
dc.identifier.citation9
dc.identifier.issn8892229
dc.identifier.other10.1089/aid.2010.0009
dc.identifier.urihttp://hdl.handle.net/10019.1/12583
dc.subjectadolescent
dc.subjectadult
dc.subjectarticle
dc.subjectcapture enzyme immunoassay
dc.subjectCD4 lymphocyte count
dc.subjectclinical trial
dc.subjectenzyme immunoassay
dc.subjectfemale
dc.subjecthealth survey
dc.subjecthuman
dc.subjectHuman immunodeficiency virus infection
dc.subjectincidence
dc.subjectmajor clinical study
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectAdult
dc.subjectCD4 Lymphocyte Count
dc.subjectEnzyme-Linked Immunosorbent Assay
dc.subjectFemale
dc.subjectHIV
dc.subjectHIV Antibodies
dc.subjectHIV Infections
dc.subjectHumans
dc.subjectIncidence
dc.titleShort communication: Simplified estimation of the long-term specificity of the BED assay to improve estimates of HIV incidence
dc.typeArticle
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