Synthesis and antimicrobial activity of the essential oil compounds (E)- and (Z)-3-hexenyl nonanoate and two analogues
dc.contributor.author | Chakravorty, Santanu | en_ZA |
dc.contributor.author | Rayner, Matthew K. | en_ZA |
dc.contributor.author | De Koning, Charles B. | en_ZA |
dc.contributor.author | Van Vuuren, Sandy F. | en_ZA |
dc.contributor.author | Van Otterlo, Willem A. L. | en_ZA |
dc.date.accessioned | 2013-07-03T08:18:43Z | |
dc.date.available | 2013-07-03T08:18:43Z | |
dc.date.issued | 2012 | |
dc.description | CITATION: Chakravorty, S. et al. 2012. Synthesis and antimicrobial activity of the essential oil compounds (E)- and (Z)-3-hexenyl nonanoate and two analogues. South African Journal of Chemistry, 65:202-205. | |
dc.description | The original publication is available at http://www.scielo.org.za | |
dc.description.abstract | The synthesis of (E)- and (Z)-3-hexenyl nonanoate, known constituents of essential oil containing plants, and two related compounds is reported. These compounds were assembled from nonanoyl chloride or nonanoic acid and the respective alcohols. In particular, it was found that the use of triethylamine as a co-solvent was necessary to avoid acid-mediated isomerization of the alkenes, which resulted in an inseparable mixture of products. The antimicrobial activity of the four hexenyl and hexyl nonanoate compounds was undertaken using microdilution minimum inhibitory concentration (MIC) analysis against eight test microorganisms. All four compounds demonstrated activity, with (E)-3-hexenyl nonanoate 1B: having the highest inhibition (MIC value of 0.45 mg mL-1) against Pseudomonas aeruginosa ATCC 27858. Furthermore, this compound demonstrated the highest broad-spectrum activity (mean MIC value of 1.24 ± 0.50 mg mL-1) with noteworthy activity against all pathogens tested. | |
dc.description.version | Publisher's version | |
dc.format.extent | 9 pages | |
dc.identifier.citation | Chakravorty, S. et al. 2012. Synthesis and antimicrobial activity of the essential oil compounds (E)- and (Z)-3-hexenyl nonanoate and two analogues. South African Journal of Chemistry, 65:202-205. | |
dc.identifier.issn | 1996-840X (online) | |
dc.identifier.issn | 0379-4350 (print) | |
dc.identifier.uri | http://hdl.handle.net/10019.1/81273 | |
dc.language.iso | en | |
dc.publisher | University of KwaZulu-Natal | |
dc.rights.holder | Authors retain copyright | |
dc.subject | Essences and essential oils -- Composition | en_ZA |
dc.subject | Anti-infective agents | en_ZA |
dc.title | Synthesis and antimicrobial activity of the essential oil compounds (E)- and (Z)-3-hexenyl nonanoate and two analogues | en_ZA |
dc.type | Article |
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