Oxidatives stress and adipocyte biology : focus on therole of AGEs
Date
2015-03
Journal Title
Journal ISSN
Volume Title
Publisher
Hindawi
Abstract
Diabetes is a major health problem that is usually associated with obesity, together with hyperglycemia and increased advanced
glycation endproducts (AGEs) formation. Elevated AGEs elicit severe downstream consequences via their binding to receptors
of AGEs (RAGE). This includes oxidative stress and oxidative modifications of biological compounds together with heightened
inflammation. For example, albumin (major circulating protein) undergoes increased glycoxidation with diabetes and may
represent an important biomarker for monitoring diabetic pathophysiology. Despite the central role of adipose tissue in many
physiologic/pathologic processes, recognition of the effects of greater AGEs formation in this tissue is quite recent within the
obesity/diabetes context. This review provides a brief background of AGEs formation and adipose tissue biology and thereafter
discusses the impact of AGEs-adipocyte interactions in pathology progression. Novel data are included showing how AGEs
(especially glycated albumin) may be involved in hyperglycemia-induced oxidative damage in adipocytes and its potential links
to diabetes progression.
Description
CITATION: Boyer, F. et al. 2015. Oxidatives stress and adipocyte biology : focus on therole of AGEs, Oxidative Medicine and Cellular Longevity, Article ID 534873, doi:10.1155/2015/534873.
The original publication is available at https://www.hindawi.com/journals/omcl
The original publication is available at https://www.hindawi.com/journals/omcl
Keywords
Diabetes, Oxidative stress, Advanced glycation endproducts, Adipocyte biology, Obesity, Hyperglycemia
Citation
Boyer, F. et al. 2015. Oxidatives stress and adipocyte biology : focus on therole of AGEs, Oxidative Medicine and Cellular Longevity, Article ID 534873, doi:10.1155/2015/534873.