Safety of psychotropic medications in people with COVID-19 : evidence review and practical recommendations

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dc.contributor.authorOstuzzi, Giovannien_ZA
dc.contributor.authorPapola, Davideen_ZA
dc.contributor.authorGastaldon, Chiaraen_ZA
dc.contributor.authorSchoretsanitis, Georgiosen_ZA
dc.contributor.authorBertolini, Federicoen_ZA
dc.contributor.authorAmaddeo, Francescoen_ZA
dc.contributor.authorCuomo, Alessandroen_ZA
dc.contributor.authorEmsley, Robinen_ZA
dc.contributor.authorFagiolini, Andreaen_ZA
dc.contributor.authorImperadore, Giuseppeen_ZA
dc.contributor.authorKishimoto, Taishiroen_ZA
dc.contributor.authorMichencigh, Giuliaen_ZA
dc.contributor.authorNose, Michelaen_ZA
dc.contributor.authorPurgato, Mariannaen_ZA
dc.contributor.authorDursun, Serdaren_ZA
dc.contributor.authorStubbs, Brendonen_ZA
dc.contributor.authorTaylor, Daviden_ZA
dc.contributor.authorThornicroft, Grahamen_ZA
dc.contributor.authorWard, Philip B.en_ZA
dc.contributor.authorHiemke, Christophen_ZA
dc.contributor.authorCorrell, Christoph U.en_ZA
dc.contributor.authorBarbui, Corradoen_ZA
dc.date.accessioned2020-07-27T07:06:02Z
dc.date.available2020-07-27T07:06:02Z
dc.date.issued2020-07-15
dc.descriptionCITATION: Ostuzzi, G., et al. 2020. Safety of psychotropic medications in people with COVID-19 : evidence review and practical recommendations. BMC Medicine, 18:215, doi:10.1186/s12916-020-01685-9.
dc.descriptionThe original publication is available at https://bmcmedicine.biomedcentral.com
dc.description.abstractBackground: The novel coronavirus pandemic calls for a rapid adaptation of conventional medical practices to meet the evolving needs of such vulnerable patients. People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. Methods: In order to produce evidence-based practical recommendations on the optimal management of psychotropic medications in people with COVID-19, an international, multi-disciplinary working group was established. The methodology of the WHO Rapid Advice Guidelines in the context of a public health emergency and the principles of the AGREE statement were followed. Available evidence informing on the risk of respiratory, cardiovascular, infective, hemostatic, and consciousness alterations related to the use of psychotropic medications, and drug–drug interactions between psychotropic and medical treatments used in people with COVID-19, was reviewed and discussed by the working group. Results: All classes of psychotropic medications showed potentially relevant safety risks for people with COVID-19. A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. Conclusions: The present evidence-based recommendations will improve the quality of psychiatric care in people with COVID-19, allowing an appropriate management of the medical condition without worsening the psychiatric condition and vice versa.en
dc.description.urihttps://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-020-01685-9
dc.description.versionPublisher's version
dc.format.extent14 pages
dc.identifier.citationOstuzzi, G., et al. 2020. Safety of psychotropic medications in people with COVID-19 : evidence review and practical recommendations. BMC Medicine, 18:215, doi:10.1186/s12916-020-01685-9
dc.identifier.issn1741-7015 (online)
dc.identifier.otherdoi:10.1186/s12916-020-01685-9
dc.identifier.urihttp://hdl.handle.net/10019.1/108728
dc.language.isoen_ZAen_ZA
dc.publisherBMC (part of Springer Nature)
dc.rights.holderAuthors retain copyright
dc.subjectCOVID-19 (Disease)
dc.subjectComorbidityen_ZA
dc.subjectDrug interactionsen_ZA
dc.subjectPsychotropic drugsen_ZA
dc.subjectPsychopharmacologyen_ZA
dc.titleSafety of psychotropic medications in people with COVID-19 : evidence review and practical recommendationsen_ZA
dc.typeArticle
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