Effect of tramadol on depth of anaesthesia

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dc.contributor.authorCoetzee J.F.
dc.contributor.authorMaritz J.S.
dc.contributor.authorDu Toit J.C.
dc.date.accessioned2011-05-15T16:15:45Z
dc.date.available2011-05-15T16:15:45Z
dc.date.issued1996
dc.description.abstractWe have studied 51 patients who were anaesthetized with propofol and suxamethonium followed by 0.7% isoflurane and 66% nitrous oxide in oxygen to see if tramadol caused lightening of anaesthesia. A two-channel EEG was recorded and music was played via headphones. Two groups received tramadol 200 and 100 mg i.v. and the third group received saline. Tramadol caused significant, dose-dependent activation of the EEG, evidenced by increased frequencies and decreased amplitudes, but these changes were small and probably unimportant. Derived EEG variables did not approach values known to be associated with near-awakening during isoflurane anaesthesia. No patient moved on skin incision and there were no incidences of free recall.
dc.description.versionArticle
dc.identifier.citationBritish Journal of Anaesthesia
dc.identifier.citation76
dc.identifier.citation3
dc.identifier.issn00070912
dc.identifier.urihttp://hdl.handle.net/10019.1/13476
dc.subjectisoflurane
dc.subjectnitrous oxide
dc.subjectoxygen
dc.subjectpropofol
dc.subjectsodium chloride
dc.subjectsuxamethonium
dc.subjecttramadol
dc.subjectadult
dc.subjectaged
dc.subjectanesthesia level
dc.subjectarousal
dc.subjectarticle
dc.subjectclinical trial
dc.subjectcontrolled clinical trial
dc.subjectcontrolled study
dc.subjectdose response
dc.subjectdrug effect
dc.subjectelectroencephalogram
dc.subjecthuman
dc.subjectintravenous drug administration
dc.subjectmajor clinical study
dc.subjectmusic
dc.subjectpriority journal
dc.subjectrandomized controlled trial
dc.subjectrecall
dc.subjectskin incision
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAnalgesics, Opioid
dc.subjectAnesthesia, Inhalation
dc.subjectAnesthetics, Inhalation
dc.subjectDose-Response Relationship, Drug
dc.subjectDrug Interactions
dc.subjectElectroencephalography
dc.subjectHumans
dc.subjectIsoflurane
dc.subjectMental Recall
dc.subjectMiddle Aged
dc.subjectNitrous Oxide
dc.subjectPropofol
dc.subjectSuccinylcholine
dc.subjectTramadol
dc.titleEffect of tramadol on depth of anaesthesia
dc.typeArticle
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