Surgical treatment of endometriosis before gamete intrafallopian transfer (GIFT)

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dc.contributor.authorVan der Merwe, J. P.en_ZA
dc.contributor.authorKruger, T. F.en_ZA
dc.contributor.authorLombard, C. J.en_ZA
dc.date.accessioned2012-08-10T18:08:33Z
dc.date.available2012-08-10T18:08:33Z
dc.date.issued2007
dc.descriptionCITATION: Van der Merwe, J. P., Kruger, T. F. & Lombard, C. J. 2007. Surgical treatment of endometriosis before gamete intrafallopian transfer (GIFT). South African Journal of Obstetrics and Gynaecology, 13(1):42-44.
dc.descriptionThe original publication is available at http://www.sajog.org.za
dc.description.abstractObjective. To determine whether active pelvic endometriosis impairs the efficacy of GIFT (gamete intrafallopian transfer) and whether prior surgical treatment of endometriosis improves the efficacy of GIFT. Design. Matched controlled retrospective study. Setting. University-based assisted reproduction programme. Patients. Patients who had GIFT between 1990 and 1997 were included in the study. Female patients were laparoscopically diagnosed as having endometriosis. Patients who did not have surgical treatment for endometriosis before GIFT were staged for endometriosis during the GIFT laparoscopy. Two patients, with no signs of endometriosis, were matched for every endometriosis case, and served as controls. Patients were matched for age, number of eggs transferred and percentage of normal sperm morphology. Intervention. Patients in 80 cycles had surgical treatment for endometriosis and 128 patients had GIFT procedures as treatment for endometriosis-related infertility. Main outcome measures. Ongoing pregnancies and deliveries. Statistical analysis. A Mantel-Haenszel approach was used to estimate relative risk of pregnancy outcome in the endometriosis groups versus controls. Results. There was a 22.9% pregnancy rate (11/48) among patients with active endometriosis who had GIFT procedures, versus a 37.0% pregnancy rate (37/100) for the controls, giving a relative risk of 0.62 (95% confidence interval (CI): 0.35 - 1.10, p = 0.082). There was a 36.3% pregnancy rate (29/80) among patients who had surgical treatment for endometriosis before GIFT, versus a 33.3% pregnancy rate (53/159) for the controls, giving a relative risk of 1.07 (95% CI: 0.75 - 1.54, p = 0.647). Conclusion. There is an indication that GIFT pregnancy rates are impared in patients suffering from active endometriosis, while prior surgery may alleviate the impairment.
dc.description.versionPublisher's version
dc.format.extent3 pages
dc.identifier.citationVan der Merwe, J. P., Kruger, T. F. & Lombard, C. J. 2007. Surgical treatment of endometriosis before gamete intrafallopian transfer (GIFT). South African Journal of Obstetrics and Gynaecology, 13(1):42-44.
dc.identifier.issn2305-8862 (online)
dc.identifier.issn2305-8862 (print)
dc.identifier.urihttp://hdl.handle.net/10019.1/41407
dc.language.isoen
dc.publisherHealth & Medical Publishing Group
dc.rights.holderAuthors retain copyright
dc.subjectEndometriosisen_ZA
dc.titleSurgical treatment of endometriosis before gamete intrafallopian transfer (GIFT)en_ZA
dc.typeArticle
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