Selection against Robertsonian fusions involving housekeeping genes in the house mouse: Integrating data from gene expression arrays and chromosome evolution

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dc.contributor.authorRuiz-Herrera A.
dc.contributor.authorFarre M.
dc.contributor.authorPonsa M.
dc.contributor.authorRobinson T.J.
dc.date.accessioned2011-05-15T15:59:02Z
dc.date.available2011-05-15T15:59:02Z
dc.date.issued2010
dc.description.abstractMonobrachial homology resulting from Robertsonian (Rb) fusions is thought to contribute to chromosomal speciation through underdominance. Given the karyotypic diversity characterizing wild house mouse populations [Mus musculus domesticus, (MMU)], variation that results almost exclusively from Rb fusions (diploid numbers range from 22 to 40) and possibly whole arm reciprocal translocations (WARTs), this organism represents an excellent model for testing hypotheses of chromosomal evolution. Previous studies of chromosome size and recombination rates have failed to explain the bias for certain chromosomes to be involved more frequently than others in these rearrangements. Here, we show that the pericentromeric region of one such chromosome, MMU19, which is infrequently encountered as a fusion partner in wild populations, is significantly enriched for housekeeping genes when compared to other chromosomes in the genome. These data suggest that there is selection against breakpoints in the pericentromeric region and provide new insights into factors that constrain chromosomal reorganizations in house mice. Given the anticipated increase in vertebrate whole genome sequences, the examination of gene content and expression profiles of the pericentromeric regions of other mammalian lineages characterized by Rb fusions (i.e., other rodents, bats, and bovids, among others) is both achievable and crucial to developing broadly applicable models of chromosome evolution. © 2010 Springer Science+Business Media B.V.
dc.description.versionArticle
dc.identifier.citationChromosome Research
dc.identifier.citation18
dc.identifier.citation7
dc.identifier.issn9673849
dc.identifier.other10.1007/s10577-010-9153-8
dc.identifier.urihttp://hdl.handle.net/10019.1/10972
dc.subjectarticle
dc.subjectbat
dc.subjectbovids
dc.subjectchromosome
dc.subjectchromosome structure
dc.subjectgene expression
dc.subjectgene expression profiling
dc.subjectgene sequence
dc.subjectgenetic selection
dc.subjectgenome
dc.subjecthousekeeping gene
dc.subjectmammalian genetics
dc.subjectmolecular evolution
dc.subjectmouse
dc.subjectmus musculus domesticus
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectRobertsonian chromosome translocation
dc.subjectrodent
dc.subjectBovidae
dc.subjectMammalia
dc.subjectMus musculus
dc.subjectMus musculus domesticus
dc.subjectRobertsonia
dc.subjectRodentia
dc.subjectVertebrata
dc.titleSelection against Robertsonian fusions involving housekeeping genes in the house mouse: Integrating data from gene expression arrays and chromosome evolution
dc.typeArticle
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