Mitogen-activated protein kinase (MAPK) in cardiac tissues

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dc.contributor.authorPage C.
dc.contributor.authorDoubell A.F.
dc.date.accessioned2011-05-15T16:00:01Z
dc.date.available2011-05-15T16:00:01Z
dc.date.issued1996
dc.description.abstractMitogen-activated protein kinase (MAPK) has recently emerged as a prominent role player in intracellular signalling in the ventricular myocyte with attention being focussed on its possible role in the development of ventricular hypertrophy. It is becoming clear that MAPK is also active in other cells of cardiac origin such as cardiac fibroblasts and possible functions of this signalling pathway in the heart have yet to be explored. In this report the mammalian MAPK pathway is briefly outlined, before reviewing current knowledge of the MAPK pathway in cardiac tissue (ventricular myocytes, vascular smooth muscle cells and cardiac fibroblasts). New data is also presented on the presence and activity of MAPK in two additional cardiac celltypes namely atrial myocytes and vascular endothelial cells from the coronary microcirculation.
dc.description.versionArticle
dc.identifier.citationMolecular and Cellular Biochemistry
dc.identifier.citation157
dc.identifier.citation02-Jan
dc.identifier.issn3008177
dc.identifier.urihttp://hdl.handle.net/10019.1/11483
dc.subjectcell receptor
dc.subjectendothelin 1
dc.subjectheart enzyme
dc.subjectmitogen activated protein kinase
dc.subjectanimal cell
dc.subjectarticle
dc.subjectcell type
dc.subjectendothelium cell
dc.subjectenzyme activation
dc.subjectenzyme activity
dc.subjectenzyme isolation
dc.subjectenzyme localization
dc.subjectfibroblast
dc.subjectheart atrium
dc.subjectheart muscle cell
dc.subjectheart ventricle hypertrophy
dc.subjectmicrocirculation
dc.subjectmuscle cell
dc.subjectnewborn
dc.subjectnonhuman
dc.subjectrat
dc.subjectsignal transduction
dc.subjectsmooth muscle fiber
dc.subjectvascular endothelium
dc.subjectvascular smooth muscle
dc.subjectAmino Acid Sequence
dc.subjectAnimals
dc.subjectCa(2+)-Calmodulin Dependent Protein Kinase
dc.subjectCardiomegaly
dc.subjectCoronary Circulation
dc.subjectFibroblasts
dc.subjectHeart
dc.subjectHumans
dc.subjectMammals
dc.subjectMicrocirculation
dc.subjectModels, Cardiovascular
dc.subjectMolecular Sequence Data
dc.subjectMyocardium
dc.subjectRats
dc.subjectSignal Transduction
dc.subjectSubstrate Specificity
dc.titleMitogen-activated protein kinase (MAPK) in cardiac tissues
dc.typeArticle
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