Molecular epidemiological interpretation of the epidemic of extensively drug-resistant tuberculosis in South Africa
Date
2015
Journal Title
Journal ISSN
Volume Title
Publisher
American Society for Microbiology
Abstract
We show that the interpretation of molecular epidemiological data for extensively drug-resistant tuberculosis (XDR-TB) is dependent on the number of different markers used to define transmission. Using spoligotyping, IS6110 DNA fingerprinting, and DNA sequence data, we show that XDR-TB in South Africa (2006 to 2008) was predominantly driven by the acquisition of second-line drug resistance.
Description
CITATION: Streicher, E. M. et al. 2015. Molecular epidemiological interpretation of the epidemic of extensively drug-resistant Tuberculosis in South Africa. Journal of Clinical Microbiology, 53:3650 –3653, doi:10.1128/JCM.01414-15.
The original publication is available at http://jcm.asm.org
The original publication is available at http://jcm.asm.org
Keywords
Extensively Drug-Resistant Tuberculosis -- Genetic aspects, Molecular epidemiology, Spoligotyping, Drug resistant tuberculosis -- Genetic aspects
Citation
Streicher, E. M. et al. 2015. Molecular epidemiological interpretation of the epidemic of extensively drug-resistant Tuberculosis in South Africa. Journal of Clinical Microbiology, 53:3650 –3653, doi:10.1128/JCM.01414-15.