Delivery of antibiotics from cementless titanium-alloy cubes may be a novel way to control postoperative infections
Date
2015-02
Journal Title
Journal ISSN
Volume Title
Publisher
Hindawi Publishing Corporation
Abstract
Bacterial colonisation and biofilm formation onto orthopaedic devices are difficult to eradicate. In most cases infection is treated
by surgical removal of the implant and cleaning of the infected area, followed by extensive treatment with broad-spectrum
antibiotics. Such treatment causes great discomfort, is expensive, and is not always successful. In this study we report on the
release of vancomycin through polyethersulfone membranes from channels in cementless titanium-alloy cubes. The cubes were
constructed with LaserCUSING from Ti6Al4V ELI powder. Vancomycin was released by non-Fickian anomalous (constraint)
diffusion. Approximately 50% of the vancomycin was released within the first 17 h. However, sustained delivery of vancomycin for
100 h was possible by reinjecting the channels. Refillable implants may be a novel way to control postoperative infections.
Description
CITATION: Bezuidenhout, Martin. B., et al. 2015. Delivery of antibiotics from cementless Titanium-Alloy cubes may be a novel way to control postoperative infections. BioMed Research International, 2015(2015), ID 856859, doi.org/10.1155/2015/856859.
The original publication is available at http://www.hindawi.com/journals/bmri/
Publication of this article was funded by the Stellenbosch University Open Access Fund.
The original publication is available at http://www.hindawi.com/journals/bmri/
Publication of this article was funded by the Stellenbosch University Open Access Fund.
Keywords
Titanium-Alloy cubes, Postoperative infections, Biofilm formation, Orthopaedic devices, Antibiotics -- Biotechnology, Infection -- Treatment, Vancomycin -- Diffusion
Citation
Bezuidenhout, Martin. B., et al. 2015. Delivery of antibiotics from cementless Titanium-Alloy cubes may be a novel way to control postoperative infections. BioMed Research International, 2015(2015), ID 856859, doi.org/10.1155/2015/856859.