Beneficial effects of adenosine triphosphate-MgC12 administered intravenously to rabbits subjected to haemorrhagic shock
Date
1986-10
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Health & Medical Publishing Group
Abstract
ENGLISH ABSTRACT: The beneficial effects of adenosine triphosphate (ATP)-MgCl2 administered as a bolus following fluid infusion or in combination with the infusion fluid were investigated in rabbits subjected to severe but reversible haemorrhagic shock. ATP-MgCl2 treatment led to a significant improvement of the metabolic functions of lung and liver tissue. Kidney tissue showed the same tendency, but the improvement did not reach significant levels. The release of lysosomal enzymes in vivo was retarded after treatment but not stopped. The mean arterial pressure was kept at a relatively constant level when ATP-MgCl2 was infused slowly. Administration as a bolus resulted in an immediate dramatic drop in pressure, followed by recovery and then a gradual decrease to levels which appeared to be incompatible with survival.
Description
CITATION: Engelbrecht, F.M. & Mattheyse, F.J. 1986. Beneficial effects of adenosine triphosphate-MgC12 administered intravenously to rabbits subjected to haemorrhagic shock. S Afr Med J, 70(10):483-486.
The original publication is available at http://www.samj.org.za
The original publication is available at http://www.samj.org.za
Keywords
Adenosine triphosphate, Haemorrhagic . . . -- Therapy, Respiratory failure -- Animals
Citation
Engelbrecht, F.M. & Mattheyse, F.J. 1986. Beneficial effects of adenosine triphosphate-MgC12 administered intravenously to rabbits subjected to haemorrhagic shock. S Afr Med J, 70(10):483-486.