In search of a treatment for HIV - Current therapies and the role of non-nucleoside reverse transcriptase inhibitors (NNRTIs)
Date
2012
Authors
Reynolds C.
De Koning C.B.
Pelly S.C.
Van Otterlo W.A.L.
Bode M.L.
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Abstract
The human immunodeficiency virus (HIV) causes AIDS (acquired immune deficiency syndrome), a disease in which the immune system progressively deteriorates, making sufferers vulnerable to all manner of opportunistic infections. Currently, world-wide there are estimated to be 34 million people living with HIV, with the vast majority of these living in sub-Saharan Africa. Therefore, an important research focus is development of new drugs that can be used in the treatment of HIV/AIDS. This review gives an overview of the disease and addresses the drugs currently used for treatment, with specific emphasis on new developments within the class of allosteric non-nucleoside reverse transcriptase inhibitors (NNRTIs). © 2012 The Royal Society of Chemistry.
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Citation
Chemical Society Reviews
41
13
4657
4670
41
13
4657
4670