A tale of two polymorphic pharmaceuticals: Pyrithyldione and propyphenazone and their 1937 co-crystal patent
Date
2011
Authors
Lemmerer A.
Bernstein J.
Griesser U.J.
Kahlenberg V.
Tobbens D.M.
Lapidus S.H.
Stephens P.W.
Esterhuysen C.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
A co-crystal of two polymorphic active pharmaceutical ingredients (APIs), first reported and patented in 1937, has been prepared and thoroughly characterised, including crystal structure analysis. The existence of four crystal forms of one of the APIs, the sedative and hypnotic active pharmaceutical ingredient 3,3-diethyl-2,4(1H,3H)-pyridinedione, pyrithyldione (PYR), and of three crystal forms of the co-crystal-forming second API, the non-steroidal anti-inflammatory drug 1,2-dihydro-1,5-dimethyl-4-(1-methylethyl)- 2-phenyl-3H-pyrazol-3-one, propyphenazone (PROP), has been reported previously, but they have only been partly characterised. For both compounds, none of the metastable forms exist at room temperature. DSC, hot-stage microscopy, X-ray diffraction and powder synchrotron X-ray diffraction were employed to characterise the polymorphic forms and to determine the crystal structures of forms I-III of PYR and forms I and II of PROP. Something old, something novel: Back in 1937, Hoffmann-LaRoche patented a co-crystal of the two active pharmaceutical ingredients pyrithyldione and propyphenazone, shown here prepared by the Kofler contact method. This is an historic example that justifies the current drive to improve physical, chemical or physiological properties by using pharmaceutical co-crystals. In addition, the crystal structures of the polymorphs of the two drug compounds have been determined for the first time by careful manipulation of the stable forms. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Description
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Keywords
Active pharmaceutical ingredients, Co-crystals, Contact methods, Crystal forms, Crystal structure analysis, Current drives, Drug compounds, Hot-stage microscopy, Metastable form, Non-steroidal anti-inflammatory drugs, Physiological properties, Polymorphic forms, Room temperature, Stable form, Synchrotron x ray diffraction, Crystals, Drug products, Polymorphism, X ray diffraction, Crystal structure
Citation
Chemistry - A European Journal
17
48
http://www.scopus.com/inward/record.url?eid=2-s2.0-81755162257&partnerID=40&md5=3c35c73e485d7cd151ceabd18e21f584
17
48
http://www.scopus.com/inward/record.url?eid=2-s2.0-81755162257&partnerID=40&md5=3c35c73e485d7cd151ceabd18e21f584