Castleman's disease and retroviral therapy
Date
2007
Authors
Kenyon C.
Pillay K.
Jacobs P.
Journal Title
Journal ISSN
Volume Title
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Abstract
The escalating pandemic of the acquired immunodeficiency disease in sub-Saharan Africa is associated with an increasing incidence of the lymphoproliferative disorders where evidence shows that highly active retroviral therapy can reconstitute immunologic competence and, at least in some groups exemplified by Kaposi's sarcoma, result in an outcome comparable to uninfected controls. Paradoxically other subtypes are less responsive exemplified by Burkitt lymphoma and multicentric Castleman's disease, where they are localised and may present after starting treatment. This association provides a model to test the concept that pathogenesis may reflect an aberrant response to antigens including human herpesvirus-8 thereby renewing focus on proactive inclusion of anti-herpes drugs with conventional treatment for retrovirus particularly prior to initiating chemotherapy. © 2007 Elsevier Ltd. All rights reserved.
Description
Keywords
ceftriaxone, efavirenz, lamivudine, proteinase inhibitor, RNA directed DNA polymerase inhibitor, stavudine, streptomycin, acquired immune deficiency syndrome, adult, angiofollicular lymph node hyperplasia, article, aspiration biopsy, Burkitt lymphoma, case report, CD4+ T lymphocyte, female, human, Human herpesvirus 8, Human immunodeficiency virus, Kaposi sarcoma, lymph node, lymphocyte count, lymphoproliferative disease, Retrovirus, treatment outcome, virotherapy, virus load, Acquired Immunodeficiency Syndrome, Adult, Africa South of the Sahara, Burkitt Lymphoma, Fatal Outcome, Female, Giant Lymph Node Hyperplasia, Herpesvirus 8, Human, Humans, Models, Biological, Reverse Transcriptase Inhibitors, Sarcoma, Kaposi, Tuberculosis, Pulmonary
Citation
Transfusion and Apheresis Science
37
1
37
1