Effect of selective noradrenergic denervation on noradrenaline content and [3H]dopamine release in rat nucleus accumbens slices
Date
1989
Authors
Russell V.A.
Lamm M.C.L.
Allin R.
De Villiers A.S.
Searson A.
Taljaard J.J.F.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
DSP4 (N-(2-chloroetyl)-N-ethyl-2-bromobenzylamine) treatment (50 mg/kg i.p., 10 days previously) significantly decreased the noradrenaline (NA) content of the rostral part of the nucleus accumbens. The medial and caudal areas were not affected. The nucleus accumbens appears to receive noradrenergic innervation predominantly from subcoeruleus nuclei of the pons-medulla while the locus coeruleus neurons project to the rostral area. The isoproterenol-induced enhancement of the K+-evoked release of [3H]dopamine (DA) was not affected by DSP4 treatment. Noradrenergic denervation does not appear to have been sufficient to cause up-regulation of postsynaptic β-adrenoceptors.
Description
Keywords
amphetamine, isoprenaline, nomifensine, radioisotope, animal cell, dopamine release, male, nonhuman, noradrenergic system, nucleus accumbens, priority journal, rat, Animal, Benzylamines, Biogenic Amines, Brain, Dopamine, In Vitro, Male, Neurotoxins, Norepinephrine, Nucleus Accumbens, Organ Specificity, Rats, Rats, Inbred Strains, Reference Values, Septal Nuclei, Support, Non-U.S. Gov't
Citation
Neurochemical Research
14
2
14
2