Regional distribution of monoamines and dopamine D1- and D2-receptors in the striatum of the rat
Date
1992, 1992
Authors
Russell V.A.
Allin R.
Lamm M.C.L.
Taljaard J.J.F.
Russell V.A.
Allin R.
Lamm M.C.L.
Taljaard J.J.F.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Dopamine (DA) D1- and D2-receptor densities were determined in 18 discrete areas of the caudate-putamen-globus pallidus of male Wistar rats and compared to local DA concentrations. All three parameters were found to decrease caudally. The globus pallidus was distinguished by the low concentration of DA and its receptors and high noradrenaline (NA) content. While there were no mediolateral differences in DA or DA D1-receptors, a clear mediolateral gradient was observed for DA D2-receptors which extended over several sections of the brain. The ratio of DA D1- to D2-receptors was significantly higher in the dorsal than in the ventral areas of the mediolateral and caudal striatum. This is the first report of clear dorsoventral differences in parameters relating to DA activity in the striatum. These findings may be of particular significance in understanding the functional dichotomy between the dorsal and ventral striatum.
Dopamine (DA) D1- and D2-receptor densities were determined in 18 discrete areas of the caudate-putamen-globus pallidus of male Wistar rats and compared to local DA concentrations. All three parameters were found to decrease caudally. The globus pallidus was distinguished by the low concentration of DA and its receptors and high noradrenaline (NA) content. While there were no mediolateral differences in DA or DA D1-receptors, a clear mediolateral gradient was observed for DA D2-receptors which extended over several sections of the brain. The ratio of DA D1- to D2-receptors was significantly higher in the dorsal than in the ventral areas of the mediolateral and caudal striatum. This is the first report of clear dorsoventral differences in parameters relating to DA activity in the striatum. These findings may be of particular significance in understanding the functional dichotomy between the dorsal and ventral striatum.
Dopamine (DA) D1- and D2-receptor densities were determined in 18 discrete areas of the caudate-putamen-globus pallidus of male Wistar rats and compared to local DA concentrations. All three parameters were found to decrease caudally. The globus pallidus was distinguished by the low concentration of DA and its receptors and high noradrenaline (NA) content. While there were no mediolateral differences in DA or DA D1-receptors, a clear mediolateral gradient was observed for DA D2-receptors which extended over several sections of the brain. The ratio of DA D1- to D2-receptors was significantly higher in the dorsal than in the ventral areas of the mediolateral and caudal striatum. This is the first report of clear dorsoventral differences in parameters relating to DA activity in the striatum. These findings may be of particular significance in understanding the functional dichotomy between the dorsal and ventral striatum.
Description
Keywords
dopamine; dopamine 1 receptor; dopamine 2 receptor; homovanillic acid; monoamine; noradrenalin; serotonin; animal tissue; article; caudate nucleus; corpus striatum; dopamine brain level; globus pallidus; kinetics; male; nonhuman; noradrenalin brain level; priority journal; putamen; rat; receptor binding; receptor density; Animal; Biogenic Monoamines; Caudate Nucleus; Comparative Study; Corpus Striatum; Globus Pallidus; Male; Putamen; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Support, Non-U.S. Gov't, dopamine, dopamine 1 receptor, dopamine 2 receptor, homovanillic acid, monoamine, noradrenalin, serotonin, animal tissue, article, caudate nucleus, corpus striatum, dopamine brain level, globus pallidus, kinetics, male, nonhuman, noradrenalin brain level, priority journal, putamen, rat, receptor binding, receptor density, Animal, Biogenic Monoamines, Caudate Nucleus, Comparative Study, Corpus Striatum, Globus Pallidus, Male, Putamen, Rats, Rats, Inbred Strains, Receptors, Dopamine, Receptors, Dopamine D1, Receptors, Dopamine D2, Support, Non-U.S. Gov't
Citation
Neurochemical Research
17
4
Neurochemical Research
17
4
17
4
Neurochemical Research
17
4