Tioconazole in the treatment of vaginal candidosis
Date
1988
Authors
Schaetzing A.
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Abstract
A 3-day treatment with tioconazole vaginal tablets (Gyno-Trosid; Pfizer) was used in 30 patients with vaginal candidosis during a prospective, mycologically controlled study. Candida yeasts were identified by microscopy and culture before initiation of treatment and then on days 3, 6 and 28. On the 6th day, all patients had responded to the treatment and there was a 100% cure rate on microscopic and mycological examination. After 4 weeks, 83% of the patients still had relief of symptoms, although a recurrence of Candida on culture and microscopy was detected in 14 patients (46%). Seven of these were available for further assessment and, when given a second course of treatment, they were cured both clinically and microbiologically. There was no evidence of any adverse systemic reaction and local side effects were limited to a transient sensation of mild to moderate burning. Problems relating to recurrence of symptoms and reappearance of Candida are discussed.
Description
Keywords
tioconazole, topical agent, adult, autopsy, candida albicans, clinical article, etiology, female, fungus, nonhuman, reinfection, relapse, topical drug administration, ultrastructure, vagina candidiasis, Adult, Antifungal Agents, Candidiasis, Vulvovaginal, Female, Human, Imidazoles, Middle Age, Prospective Studies
Citation
Mycoses
31
11
31
11