Ethanol and the placenta: A review
Date
2007, 2007
Authors
Burd L.
Roberts D.
Olson M.
Odendaal H.
Burd L.
Roberts D.
Olson M.
Odendaal H.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Objective. In this paper we review published studies of alcohol exposure on placentation, placenta growth and function. Methods. We searched PubMed using the MeSH terms: placenta, ethanol, fetal alcohol syndrome and prenatal exposure with delayed effects. We searched the years 1996-2006 and used the references from other articles to expand our search. We limited the search to English only and human only. We excluded studies using choriocarcinoma and animal studies. We grouped the 66 papers into seven topic areas for ease of review. Results. Alcohol exposure is associated with placental dysfunction, decreased placental size, impaired blood flow and nutrient transport, endocrine changes, increased rates of stillbirth and abruption, umbilical cord vasoconstriction, and low birth weight. Conclusions. Prenatal alcohol exposure has a broad range of adverse effects on placental development and function. Additional research on placental development from populations with heavy alcohol exposure should be encouraged. A tissue bank of placentas with detailed assessment of exposure to alcohol, smoking and other relevant data should be considered as a repository to support additional research. © 2007 Informa UK Ltd.
Objective. In this paper we review published studies of alcohol exposure on placentation, placenta growth and function. Methods. We searched PubMed using the MeSH terms: placenta, ethanol, fetal alcohol syndrome and prenatal exposure with delayed effects. We searched the years 1996-2006 and used the references from other articles to expand our search. We limited the search to English only and human only. We excluded studies using choriocarcinoma and animal studies. We grouped the 66 papers into seven topic areas for ease of review. Results. Alcohol exposure is associated with placental dysfunction, decreased placental size, impaired blood flow and nutrient transport, endocrine changes, increased rates of stillbirth and abruption, umbilical cord vasoconstriction, and low birth weight. Conclusions. Prenatal alcohol exposure has a broad range of adverse effects on placental development and function. Additional research on placental development from populations with heavy alcohol exposure should be encouraged. A tissue bank of placentas with detailed assessment of exposure to alcohol, smoking and other relevant data should be considered as a repository to support additional research. © 2007 Informa UK Ltd.
Objective. In this paper we review published studies of alcohol exposure on placentation, placenta growth and function. Methods. We searched PubMed using the MeSH terms: placenta, ethanol, fetal alcohol syndrome and prenatal exposure with delayed effects. We searched the years 1996-2006 and used the references from other articles to expand our search. We limited the search to English only and human only. We excluded studies using choriocarcinoma and animal studies. We grouped the 66 papers into seven topic areas for ease of review. Results. Alcohol exposure is associated with placental dysfunction, decreased placental size, impaired blood flow and nutrient transport, endocrine changes, increased rates of stillbirth and abruption, umbilical cord vasoconstriction, and low birth weight. Conclusions. Prenatal alcohol exposure has a broad range of adverse effects on placental development and function. Additional research on placental development from populations with heavy alcohol exposure should be encouraged. A tissue bank of placentas with detailed assessment of exposure to alcohol, smoking and other relevant data should be considered as a repository to support additional research. © 2007 Informa UK Ltd.
Description
Keywords
adenosine; alcohol; amino acid; androgen; biotin; chorionic gonadotropin; cytokine; epidermal growth factor; estrogen; fatty acid ester; gonadorelin; ion; progesterone; prostacyclin; pyridoxine; thromboxane; zinc; alcohol metabolism; aromatization; chorioamnionitis; choriocarcinoma; endocrine function; fetal alcohol syndrome; fetus mortality; human; intrauterine growth retardation; low birth weight; morbidity; newborn hypoxia; oxidative stress; placenta development; placenta disorder; placenta function; prenatal exposure; priority journal; protein synthesis; reproduction; review; solutio placentae; stillbirth; umbilical cord blood flow; vasculitis; vasoconstriction; Biological Transport; Ethanol; Female; Fetal Alcohol Syndrome; Fetal Death; Fetal Development; Fetal Distress; Hormones; Humans; Maternal Nutrition Physiology; Placenta; Pregnancy; Prenatal Exposure Delayed Effects; Umbilical Cord; Vasoconstriction, adenosine, alcohol, amino acid, androgen, biotin, chorionic gonadotropin, cytokine, epidermal growth factor, estrogen, fatty acid ester, gonadorelin, ion, progesterone, prostacyclin, pyridoxine, thromboxane, zinc, alcohol metabolism, aromatization, chorioamnionitis, choriocarcinoma, endocrine function, fetal alcohol syndrome, fetus mortality, human, intrauterine growth retardation, low birth weight, morbidity, newborn hypoxia, oxidative stress, placenta development, placenta disorder, placenta function, prenatal exposure, priority journal, protein synthesis, reproduction, review, solutio placentae, stillbirth, umbilical cord blood flow, vasculitis, vasoconstriction, Biological Transport, Ethanol, Female, Fetal Alcohol Syndrome, Fetal Death, Fetal Development, Fetal Distress, Hormones, Humans, Maternal Nutrition Physiology, Placenta, Pregnancy, Prenatal Exposure Delayed Effects, Umbilical Cord, Vasoconstriction
Citation
Journal of Maternal-Fetal and Neonatal Medicine
20
5
Journal of Maternal-Fetal and Neonatal Medicine
20
5
20
5
Journal of Maternal-Fetal and Neonatal Medicine
20
5