Disseminated cryptococcosis in an HIV-negative patient in South Africa: The elusive differential diagnosis
Date
2010
Authors
Mitha M.
Naicker P.
Mahida P.
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Abstract
The presence of an opportunistic infection in a patient in sub-Saharan Africa is assumed to be due to underlying immunosuppression from human immunodeficiency virus (HIV) infection. The presence of disseminated cryptococcosis in a non-HIV-infected patient is interesting as it is unique in our setting because the majority of infections are found in HIV-infected individuals. The protean manifestations of the disease and its predilection for immunosuppressed patients make cryptococcosis a challenging and elusive disease to diagnose in HIV-negative patients in our setting, especially due to limited resources. We present a case of disseminated cryptococcosis in an immunocompetent patient and discuss diagnostic and therapeutic features in this subset of patients. © 2010 Mitha et al.
Description
Keywords
amphotericin B, fluconazole, tuberculostatic agent, adult, anamnesis, article, brain edema, brain scintiscanning, case report, computer assisted tomography, cryptococcosis, differential diagnosis, disease course, disseminated cryptococcosis, frontal lobe, human, Human immunodeficiency virus, immunocompetence, kidney disease, male, South Africa, tuberculoma, Acute Kidney Injury, Adult, Amphotericin B, Antifungal Agents, Brain, Cryptococcosis, Cryptococcus neoformans, Diagnosis, Differential, Fluconazole, Humans, Male, South Africa, Tomography, X-Ray Computed, Human immunodeficiency virus, Protea
Citation
Journal of Infection in Developing Countries
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