Minimal inhibitory concentration of isoniazid in isoniazid-resistant Mycobacterium tuberculosis isolates from children
Date
2006
Authors
Schaaf H.S.
Victor T.C.
Engelke E.
Brittle W.
Marais B.J.
Hesseling A.C.
Van Helden P.D.
Donald P.R.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The aim of the study presented here was to determine the minimal inhibitory concentration of isoniazid for strains of isoniazid-resistant or multidrug-resistant Mycobacterium tuberculosis isolated from children in the Western Cape Province of South Africa. During the period March 2003-October 2005, 45 INH-resistant M. tuberculosis isolates (21 also rifampicin-resistant) were cultured from children less than 13 years of age. Drug susceptibility testing by the radiometric BACTEC 460 method found 11 isolates resistant at 0.1 μg/ml, 27 resistant at 0.2 μg/ml, and seven resistant at ≥5 μg/ml. Thus, the minimal inhibitory concentration of isoniazid for more than 80% of the isoniazid-resistant strains isolated from children in this study was relatively low and could be exceeded by high-dose (15-20 mg/kg) isoniazid regimens. © 2007 Springer-Verlag.
Description
Keywords
isoniazid, rifampicin, adolescent, antibiotic resistance, article, bacterial strain, bacterium culture, bacterium isolate, human, microbiological examination, minimum inhibitory concentration, multidrug resistance, Mycobacterium tuberculosis, nonhuman, priority journal, radiometry, South Africa, Adolescent, Antitubercular Agents, Child, Child, Preschool, Drug Resistance, Bacterial, Drug Resistance, Multiple, Bacterial, Humans, Infant, Isoniazid, Microbial Sensitivity Tests, Mycobacterium tuberculosis, Rifampin, Tuberculosis
Citation
European Journal of Clinical Microbiology and Infectious Diseases
26
3
26
3