Contraceptive efficacy of 200μg R2323 and 10μg R2858
Date
1981
Authors
Rall H.J.S.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Investigation into the contraceptive efficacy of 200 μg R2323 (13-ethyl-17-hydroxy-18, 19-dinor-17α-pregna-4, 9, 11-trien-20-yn-3-one) and 10 μg R2858 (11β-methoxy-17α-ethinyl-oestradiol) as a combination pill, was carried out in a group of 86 healthy females of proven fertility during 667 cycles (mean 7.74 cycles). A total of 10 pregnancies occurred for a pregnancy rate of 19.5, computed by the Pearl formula, but only four were considered drug failures. Although side-effects were generally minimal, one case of cerebral thrombosis was reported. Only two women complained of menorrhagia and three developed amenorrhoea while on therapy. Papanicolaou smears were taken at two- to three-month intervals for a total of 161 smears and no malignant changes were recorded.
Description
Keywords
contraceptive agent, gestrinone, moxestrol, adverse drug reaction, contraception, menorrhagia, methoxyethinylestradiol, occlusive cerebrovascular disease, oral drug administration, pregnancy, prevention, secondary amenorrhea
Citation
Clinical Trials Journal
18
6
18
6