Major flares in women with SLE on combined oral contraception
Date
2007
Authors
Whitelaw D.A.
Jessop S.J.
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Abstract
Two recent trials concluded that the use of oral contraceptives (OC) did not induce flares in lupus patients. We record our experience with OC in patients with stable lupus. Eight patients were enrolled in an open trial. Six received a combined contraceptive pill and two were allocated to the control arm. During a 12 month follow-up, 3 patients in the active arm experienced 4 major flares. One patient died as a result of uncontrolled disease complicated by sepsis. At this point, we abandoned the trial. The 2 patients in the control arm experienced no disease exacerbation during the 7 months of observation. We would urge that patients who are placed on OC be closely monitored. © Clinical Rheumatology 2007.
Description
Keywords
antibiotic agent, azathioprine, creatine kinase, cyclophosphamide, estrogen, ethinylestradiol plus levonorgestrel, methotrexate, methylprednisolone, oral contraceptive agent, prednisone, adult, arthritis, article, clinical feature, clinical trial, controlled clinical trial, controlled study, creatine kinase blood level, disease activity, disease control, disease severity, drug pulse therapy, drug response, drug withdrawal, dyspnea, echocardiography, fatality, female, fever, follow up, human, kidney biopsy, leukocytosis, low drug dose, lung infiltrate, myocarditis, myositis, nephritis, open study, oral contraception, patient monitoring, pericardial effusion, premenopause, priority journal, relapse, sepsis, systemic lupus erythematosus, thorax pain, urine sediment, vasculitic rash, weakness, Adult, Contraceptives, Oral, Female, Follow-Up Studies, Hot Flashes, Humans, Lupus Erythematosus, Systemic, Middle Aged, Prognosis, Retrospective Studies, Risk Factors
Citation
Clinical Rheumatology
26
12
26
12