Immunosuppressive therapy for pemphigus vulgaris complicated by malakoplakia of the bladder
Date
1990
Authors
Jordaan H.F.
Heyns C.F.
Allen F.J.
Schneider J.
Journal Title
Journal ISSN
Volume Title
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Abstract
Pemphigus vulgaris is an uncommon auto-immune disease which responds well to treatment with corticosteroids and azathioprine. Malakoplakia is a rare granulomatous disease associated with coliform infections and an altered cellular immune response. We report a 68-year-old female patient with pemphigus vulgaris who, after 2 years on maintenance prednisone and azathioprine immunotherapy, developed malakoplakia of the bladder associated with chronic E. coli urinary-tract infection. The malakoplakia responded well to treatment with cotrimoxazole, bethanechol chloride and ascorbic acid, combined with tapering of the corticosteroid dosage. Our patient presents an uncommon but interesting complication of long-term immunosuppressive therapy for pemphigus vulgaris.
Description
Keywords
ascorbic acid, azathioprine, bethanechol, cotrimoxazole, prednisone, aged, article, bladder, case report, female, histology, human, human cell, malacoplakia, oral drug administration, pemphigus vulgaris, priority journal, Aged, Azathioprine, Bladder Diseases, Case Report, Escherichia coli Infections, Female, Human, Immunosuppression, Malacoplakia, Pemphigus, Prednisolone, Urinary Tract Infections
Citation
Clinical and Experimental Dermatology
15
6
15
6