Effect of semen characteristics on pregnancy rate in a gamete intrafallopian transfer program
Date
1993
Authors
Kruger T.F.
Franken D.R.
Stander E.
Swart Y.
Van der Merwe J.P.
Journal Title
Journal ISSN
Volume Title
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Abstract
The aim of this study was to evaluate the influence of sperm morphology, swim-up concentration, and insemination volume on pregnancy outcome in patients undergoing gamete intrafallopian transfer (GIFT) treatment in whom the male partner had a morphology of less than 14%. Only patients who received four oocytes were entered into this study (n=103). In all cases the swim-up procedure time was standardized to 1 h and the insemination concentration was standardized to 500,000 per oviduct. There was no significant difference in pregnancy rate when normal morphology, swim-up concentration, or insemination volume were used as predictors. In the P pattern group (<4% normal forms) only four of the 28 (14%) patients had ongoing pregnancies, whereas in the G pattern group (5% to 14% normal forms) 16 out of 75 (21%) had ongoing pregnancies (P vs G, p > 0.05; not significant). The fertilization rate among excess oocytes in the p pattern group was 18% but was 39% (p < .0001) in the G pattern group. When an attempt was made to compensate for low morphology by increasing insemination concentration no significant difference in the pregnancy rate between the P and G pattern groups in the GIFT program was recorded. This was not the case when the in vitro fertilization rate was used as an endpoint. Insemination volume and swim-up concentration played no role in pregnancy rate.
Description
Keywords
article, controlled study, female, gamete intrafallopian transfer, human, human tissue, infertility, male, pregnancy rate, priority journal, seminal plasma, spermatozoon count, spermatozoon motility, Female, Gamete Intrafallopian Transfer, Human, Male, Pregnancy, Semen, Sperm Count
Citation
Archives of Andrology
31
2
31
2