The sensing of nutritional status and the relationship to filamentous growth in Saccharomyces cerevisiae
Date
2002
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Heterotrophic organisms rely on the ingestion of organic molecules or nutrients from the environment to sustain energy and biomass production. Non-motile, unicellular organisms have a limited ability to store nutrients or to take evasive action, and are therefore most directly dependent on the availability of nutrients in their immediate surrounding. Such organisms have evolved numerous developmental options in order to adapt to and to survive the permanently changing nutritional status of the environment. The phenotypical, physiological and molecular nature of nutrient-induced cellular adaptations has been most extensively studied in the yeast Saccharomyces cerevisiae. These studies have revealed a network of sensing mechanisms and of signalling pathways that generate and transmit the information on the nutritional status of the environment to the cellular machinery that implements specific developmental programmes. This review integrates our current knowledge on nutrient sensing and signalling in S. cerevisiae, and suggests how an integrated signalling network may lead to the establishment of a specific developmental programme, namely pseudohyphal differentiation and invasive growth. © 2002 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.
Description
Keywords
carbon, G protein coupled receptor, nitrogen, mitogen activated protein kinase, adaptation, bioavailability, biomass production, energy, energy resource, environment, fungus growth, heterotrophy, ingestion, microorganism, molecular biology, molecular mechanics, molecule, nonhuman, nutrient, nutritional status, phenotype, remote sensing, review, Saccharomyces cerevisiae, sensation, signal processing, signal transduction, yeast, cell differentiation, fungus hyphae, gene expression regulation, genetics, growth, development and aging, metabolism, physiology, Saccharomyces cerevisiae, Adaptation, Physiological, Carbon, Cell Differentiation, Gene Expression Regulation, Fungal, Hyphae, Mitogen-Activated Protein Kinases, Nitrogen, Saccharomyces cerevisiae, Signal Transduction
Citation
FEMS Yeast Research
2
4
2
4