Characterization and phylogenetic analysis of South African HIV-1 subtype C accessory genes
Date
2001
Authors
Scriba T.J.
Treurnicht F.K.
Zeier M.
Engelbrecht S.
Van Rensburg E.J.
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Journal ISSN
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Abstract
To acquire new knowledge about the genetic diversity and potential impact on vaccine strategies of HIV-1 subtype C in South Africa, we have characterized the vif, vpr, and vpu genes of 15 isolates. Phylogenetic analysis of the genomic fragment encompassing these genes revealed subtype C subclusters, suggesting close relatedness with subtype C strains from other geographic locations and excluded isolation of South African strains. The putative T155 phosphorylation site in the C terminal of Vif was absent in all subtype C sequences. Variation in the predicted amino acid sequences of the three genes further showed strong correlation with other subtype C sequences.
Description
Keywords
Human immunodeficiency virus vaccine, Vif protein, Vpr protein, Vpu protein, amino acid sequence, article, carboxy terminal sequence, clinical article, controlled study, female, gene isolation, genetic analysis, geographic distribution, human, Human immunodeficiency virus 1, male, nucleotide sequence, phylogeny, priority journal, protein phosphorylation, South Africa, virus characterization, virus strain, AIDS Vaccines, Amino Acid Sequence, Female, Genes, vif, Genes, Viral, Genes, vpr, Genes, vpu, HIV Infections, HIV-1, Humans, Male, Molecular Sequence Data, Phylogeny, Sequence Alignment, South Africa, Variation (Genetics)
Citation
AIDS Research and Human Retroviruses
17
8
17
8