Molecular analysis of HIV type 1 vif sequences from Cape Town, South Africa
Date
2008
Authors
Jacobs G.B.
Nistal M.
Laten A.
Van Rensburg E.J.
Rethwilm A.
Preiser W.
Bodem J.
Engelbrecht S.
Journal Title
Journal ISSN
Volume Title
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Abstract
South Africa has the highest number of HIV-1-infected individuals in the world, with HIV-1 subtype C prevailing. However, HIV-1 subtype C accessory genes are rarely characterized in the country. These genes are important for establishing viral pathogenesis. The Vif protein has been shown to counteract the antiretroviral activity of APOBEC3G/F cytidine deaminases. In this study an additional 50 HIV-1 vif sequences are characterized. These include 48 HIV-1 subtype C and 2 HIV-1 subtype B sequences. Highly conserved HIV-1 subtype C motifs are outlined. The previously identified RLRR (90-93) motif does not seem to be conserved among our newly analyzed sequences. Conserved motifs can be useful for developing new vaccine strategies or antiretroviral drugs. © 2007 Mary Ann Liebert, Inc.
Description
Keywords
apolipoprotein B messenger RNA editing enzyme catalytic polypeptide 3F, apolipoprotein B messenger RNA editing enzyme catalytic polypeptide 3G, Vif protein, amino acid sequence, article, clinical article, controlled study, female, human, Human immunodeficiency virus 1, Human immunodeficiency virus 1 infection, male, nucleotide sequence, phylogenetic tree, polymerase chain reaction, priority journal, protein motif, sequence analysis, South Africa, unindexed sequence, virus pathogenesis, Amino Acid Motifs, Amino Acid Sequence, Female, Gene Products, vif, HIV Infections, HIV-1, Humans, Male, Molecular Sequence Data, Sequence Alignment, South Africa
Citation
AIDS Research and Human Retroviruses
24
7
24
7