Short communication: Simplified estimation of the long-term specificity of the BED assay to improve estimates of HIV incidence
Date
2010
Authors
Hargrove J.
Humphrey J.
Journal Title
Journal ISSN
Volume Title
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Abstract
The BED assay overestimates HIV incidence because a proportion, epsilon (ω), of chronically infected people test "false-recent." In the ZVITAMBO trial, 2796 postpartum women tested HIV positive at baseline and 5.1% tested "false-recent" by BED 12 months later, providing a population-based estimate of ω. At baseline, 7.2% (95% CI: 5.3-9.4) of positive women >30 years and 5.1% (95% CI: 3.5-7.2) of positive women with CD4 <200 cells/μl tested "recent" by BED. Thus, the proportions of BED-positive women in either of these subgroups (data that would be available in surveys measuring HIV and BED status) provided a reasonably tight upper bound for ω, which can be used to provide a lower bound for HIV incidence. © 2010, Mary Ann Liebert, Inc.
Description
Keywords
adolescent, adult, article, capture enzyme immunoassay, CD4 lymphocyte count, clinical trial, enzyme immunoassay, female, health survey, human, Human immunodeficiency virus infection, incidence, major clinical study, nonhuman, priority journal, Adult, CD4 Lymphocyte Count, Enzyme-Linked Immunosorbent Assay, Female, HIV, HIV Antibodies, HIV Infections, Humans, Incidence
Citation
AIDS Research and Human Retroviruses
26
9
26
9