A comparison of labetalol, acebutolol, and lidocaine for controlling the cardiovascular responses tool endotracheal intubation for oral surgical procedures
Date
1987
Authors
Roelofse J.A.
Shipton E.A.
Joubert De J.J.V.
Grotepass F.W.
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Journal ISSN
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Abstract
Arterial blood pressure and pulse rate changes following tracheal intubation were studied in 80 patients undergoing oral surgical procedures who received an etomidate/suxamethonium anesthetic induction sequence. Three treatment groups and a control group were used. Intravenous labetalol (1 mg/kg), acebutolol (0.25 mg/kg), lidocaine (2 mg/kg), and saline (1 ml), injected prior to anesthesia, were compared with respect to their effects on the hemodynamic consequences of direct laryngoscopy followed by the passage of an endotracheal tube. A pre-induction dose of labetalol was found to be more effective than acebutolol and lidocaine in attenuating the pressor response to instrumentation and intubation. Labetalol should prove most useful for those patients at risk from the transient hypertension and tachycardia following instrumentation and intubation.
Description
Keywords
acebutolol, labetalol, lidocaine, anesthesia, cardiovascular response, cardiovascular system, drug comparison, endotracheal intubation, human, major clinical study, mouth, oral surgery, respiratory system, therapy, Acebutolol, Adult, Anesthesia, Dental, Anesthesia, General, Blood Pressure, Comparative Study, Female, Hemodynamics, Human, Intubation, Intratracheal, Labetalol, Laryngoscopy, Lidocaine, Male, Mouth, Preanesthetic Medication, Pulse
Citation
Journal of Oral and Maxillofacial Surgery
45
10
45
10