Comparison of sublingual lorazepam with intramuscular diazepam as sedatives during oral surgery
Date
1988
Authors
Van Der Bijl P.
Roelofse J.A.
De Joubert V.J.J.
Journal Title
Journal ISSN
Volume Title
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Abstract
Sublingual lorazepam (2 to 3 mg) was compared with intramuscular diazepam (0.25 mg/kg) and placebo for sedation during oral surgery under local anesthesia. Sixty patients were randomly allocated into three groups in this double-blind, parallel study. The results from this trial show that sublingually administered lorazepam provided good sedation and anxiolysis. More side-effects, such as giddiness, dizziness, and ptosis, as well as profound and prolonged psychomotor impairment, were, however, found in the lorazepam group than in those patients who had received intramuscular diazepam (0.25 mg/kg) or placebo.
Description
Keywords
diazepam, lorazepam, controlled study, human, intramuscular drug administration, local anesthesia, major clinical study, oral surgery, priority journal, ptosis, sedation, sublingual drug administration, vertigo, Administration, Sublingual, Adolescent, Adult, Comparative Study, Diazepam, Double-Blind Method, Female, Human, Injections, Intramuscular, Lorazepam, Male, Preanesthetic Medication, Random Allocation, Statistics, Tablets, Tooth Extraction
Citation
Journal of Oral and Maxillofacial Surgery
46
7
46
7