Preanesthetic medication with rectal midazolam in children undergoing dental extractions
Date
1990
Authors
Roelofse J.A.
Van der Bijl P.
Stegmann D.H.
Hartshorne J.E.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Three different dosages (0.25, 0.35, and 0.45 mg/kg) of rectally administered midazolam were compared with each other and with placebo for preanesthetic medication in children undergoing dental extractions. Eighty patients between the ages of 2 and 10 years were randomly allocated into four groups in this double-blind study. The results from this trial show that 30 minutes after rectal administration of all doses of midazolam, good anxiolysis, sedation, and cooperation were obtained in most patients. A high prevalence (23%) of disinhibition reactions was observed, particularly in the 0.45 mg/kg group. For this reason, 0.25 or 0.35 mg/kg appears to be the dose of choice when rectal midazolam is used for premedication in children.
Description
Keywords
midazolam, anesthesia, article, child, confusion, dental surgery, human, premedication, priority journal, psychological aspect, rectal drug administration, visual disorder, Administration, Rectal, Analysis of Variance, Anesthesia, Dental, Anesthesia, General, Chi-Square Distribution, Child, Child, Preschool, Comparative Study, Double-Blind Method, Female, Human, Male, Midazolam, Preanesthetic Medication, Randomized Controlled Trials, Tooth Extraction
Citation
Journal of Oral and Maxillofacial Surgery
48
8
48
8