Lack of effect of phenobarbitone treatment on metabolism and brain uptake of delta aminolaevulinic acid in rats
Date
1977
Authors
Percy V.A.
Shanley B.C.
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Abstract
Rats were treated daily with phenobarbitone and delta aminolaevulinic acid (ALA) for 5 days. Phenobarbitone treatment had no significant effect on ALA metabolism and excretion or on ALA uptake into brain tissue. No significant behavioral effects other than those attributable to phenobarbitone alone were observed. These results do not support the suggestion that porphyrinogenic drugs may precipitate acute neuropathic effects in the hereditary hepatic porphyrias through altering porphyrin precursor metabolism or uptake of these compounds by neural tissue.
Description
Keywords
aminolevulinic acid, cytochrome p450, phenobarbital, behavior, blood brain barrier, brain, drug absorption, drug metabolism, intraperitoneal drug administration, liver cell, microsome, oral drug administration, porphyria, rat, serum, theoretical study, urine, Aminolevulinic Acid, Animal, Brain, Comparative Study, Cytochrome P-450 Enzyme System, Female, Levulinic Acids, Liver, Phenobarbital, Porphobilinogen, Rats
Citation
Biochemical Pharmacology
26
8
26
8