Effects of adriamycin on heart and skeletal muscle chromatin
Date
1982
Authors
Van Helden P.D.
Wiid I.J.F.
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Abstract
Interactions between adriamycin (ADM) and chromatin from heart and skeletal muscle from 15 day-old chicken emryos were investigated. Adriamycin interacts with the DNA of chromatin and this interaction is modified by the chromatin proteins. One of the effects of this interaction is an increase in the melting temperature (T(m)) of the DNA, where adriamycin is observed to increase the T(m) of heart chromatin to a greater extent than skeletal muscle chromatin. Adriamycin also inhibits in vitro DNA and RNA synthesis in isolated chromatin and nuclei. This inhibition is observed to be greater in heart muscle. Inhibition of transcription in the myocardium could be a major cause of adriamycin-induced cardiomyopathy.
Description
Keywords
doxorubicin, animal experiment, cardiomyopathy, chicken, chromatin, dna drug complex, dna synthesis, embryo, heart, heart muscle, heredity, in vitro study, muscle, rna synthesis, Animal, Chick Embryo, Chromatin, DNA, Doxorubicin, Heart, Muscles, Myocardium, RNA
Citation
Biochemical Pharmacology
31
6
31
6