Changes in regional brain volumes in social anxiety disorder following 12 weeks of treatment with escitalopram
Date
2010
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Abstract
It has been suggested that antidepressants, including the selective serotonin reuptake inhibitors have neurotrophic effects. Nevertheless, the impact of treatment with a selective serotonin re-uptake inhibitor on regional brain volumes in social anxiety disorder has not been studied. 11 subjects with social anxiety disorder completed magnetic resonance imaging both before and after 12-weeks of treatment with 20 mg/day escitalopram. No increases in structural grey matter were found, but there were decreases in bilateral superior temporal cortex, vermis and the left cerebellum volumes following 12 weeks of treatment with escitalopram. These preliminary findings require replication to determine their reliability, and extension to determine whether or not they are disorder specific. © 2010 Springer Science+Business Media, LLC..
Description
Keywords
escitalopram, adult, aged, article, brain size, cerebellum vermis, clinical article, female, gray matter, human, male, nuclear magnetic resonance imaging, social phobia, temporal cortex, treatment outcome, Adolescent, Adult, Aged, Anxiety, Anxiety Disorders, Brain, Citalopram, Depressive Disorder, Diagnostic and Statistical Manual of Mental Disorders, Female, Frontal Lobe, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Patient Compliance, Psychiatric Status Rating Scales, Serotonin Uptake Inhibitors, Temporal Lobe, Young Adult
Citation
Metabolic Brain Disease
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