BDI-modelling of complex intracellular dynamics
Date
2008
Authors
Jonker C.M.
Snoep J.L.
Treur J.
Westerhoff H.V.
Wijngaards W.C.A.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
A BDI-based continuous-time modelling approach for intracellular dynamics is presented. It is shown how temporalised BDI-models make it possible to model intracellular biochemical processes as decision processes. By abstracting from some of the details of the biochemical pathways, the model achieves understanding in nearly intuitive terms, without losing veracity: classical intentional state properties such as beliefs, desires and intentions are founded in reality through precise biochemical relations. In an extensive example, the complex regulation of Escherichia coli vis-à-vis lactose, glucose and oxygen is simulated as a discrete-state, continuous-time temporal decision manager. Thus a bridge is introduced between two different scientific areas: the area of BDI-modelling and the area of intracellular dynamics. © 2007 Elsevier Ltd. All rights reserved.
Description
Keywords
glucose, lactose, oxygen, bacterium, biochemistry, catabolism, decision making, microbial activity, modeling, algorithm, article, behavioral science, cytology, decision making, Escherichia coli, priority journal, scientific literature, simulation, Animals, Computer Simulation, Escherichia coli, Glucose, Intracellular Space, Lactose, Models, Biological, Models, Chemical, Oxygen, Systems Biology, Bacteria (microorganisms), Escherichia coli
Citation
Journal of Theoretical Biology
251
1
251
1