Novel N-heterocyclic ylideneamine gold(i) complexes: Synthesis, characterisation and screening for antitumour and antimalarial activity
Date
2011
Authors
Coetzee J.
Cronje S.
Dobrzanska L.
Raubenheimer H.G.
Joone G.
Nell M.J.
Hoppe H.C.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Ylideneamine functionalised heterocyclic ligands, 1,3-dimethyl-1,3-dihydro- benzimidazol-2-ylideneamine (I), 3-methyl-3H-benzothiazol-2-ylideneamine (II) or 3,4-dimethyl-3H-thiazol-2-ylideneamine (III), were employed in the preparation of a series of both charged and neutral gold(i) complexes consisting either of a Au(C6F5) fragment (1-3), a [Au(PPh3)] + unit (4-6) or a [Au(NHC)]+ unit (7) coordinated to the imine nitrogen of the neutral ylideneamine ligand. These complexes were fully characterised by various techniques including X-ray diffraction. In addition, the antitumour and antimalarial potential of selected compounds were assessed in a preliminary study aimed at determining the medicinal value of such compounds. Complexation of the azol-2-ylideneamine ligands with [Au(PPh3)] + increases their antitumour as well as antimalarial activity. © 2011 The Royal Society of Chemistry.
Description
Keywords
Antimalarial activity, Characterisation, Heterocyclic ligands, N-heterocyclic, Ligands, Organic compounds, Synthesis (chemical), X ray diffraction, Gold compounds
Citation
Dalton Transactions
40
7
40
7