Cardioprotection conferred by rooibos (Aspalathus linearis) : a mini review to highlight a potential mechanism of action
Date
2019
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Academy of Science of South Africa
Abstract
ENGLISH ABSTRACT: A number of cardioprotective interventions have been identified throughout the years, and these include the use of natural antioxidants in sources like rooibos (Aspalathus linearis) tea. Recent studies have demonstrated that rooibos (either its isolated components or the crude rooibos extract/tea) confers cardioprotection in diabetic cardiomyopathy and myocardial ischaemic injury. In addition, a clinical study has shown that regular rooibos consumption reduces the risk for cardiovascular disease in adults. However, rooibos is currently not considered an official treatment against cardiac disease, mainly because the underlying mechanisms for rooibos-induced cardioprotection are not fully elucidated. Physiological actions of rooibos must be well investigated before rooibos can be used in a clinical setting as adjunct treatment for patients with heart disease. Thus, research to delineate the underlying mechanisms of rooibos-induced cardioprotection is key. In the light of the aforementioned, the available literature on rooibos-induced cardioprotection is reviewed here, highlighting the fact that rooibos preserves and maintains cardiac energy homeostasis. It is postulated that rooibos activates an AMPK-GLUT-4 glucose oxidation (cardiac energy-shortage sensing) pathway to shift cardiac energy usage, thereby conferring cardioprotection.
Description
CITATION: Maarman, G. J. 2019. Cardioprotection conferred by rooibos (Aspalathus linearis) : a mini review to highlight a potential mechanism of action. South African Journal of Science, 115(7/8), Art. #4653, doi:10.17159/sajs.2019/4653.
The original publication is available at http://sajs.co.za
The original publication is available at http://sajs.co.za
Keywords
Medicinal plants, Cardioprotective agents, Aspalathus linearis
Citation
Maarman, G. J. 2019. Cardioprotection conferred by rooibos (Aspalathus linearis) : a mini review to highlight a potential mechanism of action. South African Journal of Science, 115(7/8), Art. #4653, doi:10.17159/sajs.2019/4653