Induced candidosis in mice with artificially established oral flora.
Date
1996
Authors
van Wyk C.W.
Basson N.J.
Theunissen F.
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Abstract
The aim of this study was to gauge the effect of an artificially established flora, unnatural for mice, on the induction of oral candidosis in mice. Four groups of BALB/c mice were compared; conventional Candida albicans-free mice, "germ-free" mice which had been inoculated with Candida-free human saliva, germ-free mice which had been exposed to a cocktail of Streptococcus mitis, S. sobrinus and S. sanguis, and uncontaminated germ-free mice. After exposure to C. albicans via drinking water, the four groups of mice were killed and their oral cavities examined for candidal growth and oral lesions. Conventional mice yielded significantly less candidal growth and exhibited significantly fewer oral lesions than the other three groups. Candidal lesions in the two groups of contaminated germ-free mice were significantly fewer than in the uncontaminated germ-free mice. The latter exhibited extensive candidal lesions with little inflammatory infiltrate. It is concluded that mice with human oral micro-organisms have some resistance against candidal infection albeit at a reduced level, that mice with natural oral flora are highly resistant, and that germ-free mice are extremely susceptible to C. albicans infection.
Description
Keywords
animal, article, Bagg albino mouse, candidiasis, comparative study, disease predisposition, germfree animal, human, male, microbiology, mouse, mouth, randomization, Streptococcus, Animals, Candidiasis, Disease Susceptibility, Humans, Male, Mice, Mice, Inbred BALB C, Mouth, Random Allocation, Specific Pathogen-Free Organisms, Streptococcus
Citation
The Journal of the Dental Association of South Africa = Die Tydskrif van die Tandheelkundige Vereniging van Suid-Afrika
51
7
51
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