Comparison of the effects of propofol and halothane on acute myocardial ischaemia and myocardial reperfusion injury
Date
1996
Authors
Coetzee A.
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Abstract
The effects of two blood concentrations of propofol on acute severe regional myocardial ischacmia (15-minute occlusion of the LAD coronary artery) and 2-hour reperfusion were studied in 10 pigs. Results were contrasted with the effect of 0.8% halothane (N = 5). Results indicate that during acute ischaemia, regional myocardial function of the segment supplied by the LAD artery was not protected against the effects of ischaemia in the propofol or halothane groups. During reperfusion, animals subjected to halothane demonstrated significantly fewer reperfusion arrhythmias and segmentai function was less stunned than in either propofol group. There was no difference in heart performance between the propofol groups. Results indicate that the proposed anti-oxidant effect of propofol is not sufficient to protect the animal heart from reperfusion injury.
Description
Keywords
halothane, propofol, animal experiment, antioxidant activity, article, controlled study, coronary artery blood flow, drug effect, heart muscle ischemia, heart perfusion, nonhuman, reperfusion injury, swine, Anesthetics, Inhalation, Animals, Free Radical Scavengers, Halothane, Myocardial Ischemia, Propofol, Reperfusion Injury, Swine
Citation
Cardiovascular Journal of South Africa
SUPPL. 2
SUPPL. 2