The metabolic syndrome, insulin resistance and cardiovascular disease
Date
2002
Authors
Ascott-Evans B.
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Abstract
In westernised societies the metabolic syndrome (MS) is common and primarily a lifestyle disease with significant morbidity and premature mortality. The main end-points are related to cardiovascular disease (CVD), especially affecting the heart. Although insulin resistance (and hyperinsulinaemia) is an early marker of MS and future adverse cardiovascular outcomes, it is not known if on its own this is sufficient. The issue is further clouded in prospective studies by the development in study subjects of some, or all of the components of MS, each of which is an independent risk factor for CVD! Therefore, in spite of a number of appropriate longterm observational studies, we are unable to tease out the exact contribution of the individual components of MS, which together are unequivocally responsible for this present-day epidemic of CVD.
Description
Keywords
cardiovascular disease, disease marker, human, hyperinsulinemia, insulin resistance, lifestyle, metabolic disorder, morbidity, mortality, non insulin dependent diabetes mellitus, prospective study, review, risk factor, Cardiovascular Diseases, Humans, Insulin Resistance, Metabolic Syndrome X, Obesity, Prospective Studies
Citation
Cardiovascular Journal of South Africa
13
4
13
4