Browsing by Author "Gericke, G. S."
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- ItemLeukaemogenesis in Down's syndrome(Health & Medical Publishing Group, 1977) Gericke, G. S.; Hesseling, P. B.; Brink, S.; Becker, W. B.Due to the fixed karotype and documented malignancy risk in patients with Down's syndrome, recently described aetiological factors can be assigned to their proper places in a conceptual framework for leukaemogenesis in these individuals. This is a more profitable approach than those in which various types of karyotypic patterns are matched to different malignancies. It seems that viruses may play a special role, but they need interaction with other factors, most of which are present in Down's syndrome. A unifying concept which may be helpful in establishing research priorities is presented.
- ItemMucolipidosis III: two patients displaying genetic pleiotropism(HMPG, 1977-01) Gericke, G. S.Two Cape Colored siblings with typical features of Hurler's syndrome, but without mucopolysacchariduria or mucopolysaccharide accumulation in tissues, are presented. The clinical features, in conjunction with raised β D galactosidase and α L fucosidase levels in fibroblast cultures from 1 of the patients, suggest the diagnosis of a mucolipidosis. Theories relating to the intracellular deficiency and extracellular excess of lysosomal enzymes in these conditions are reviewed. Phenotypical and cell culture differences between 2 siblings who display the same overall clinical syndrome, illustrate the genetic pleiotropism inherent in this group of diseases.